{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:54:35Z","timestamp":1784555675798,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Although buprenorphine\u2010based opioid agonist maintenance treatment (OAMT) is effective, logistical, economic and stigma\u2010related barriers limit access. Telemedicine\u2010Assisted Buprenorphine Induction (TABI) may address these barriers. This study evaluated the non\u2010inferiority of TABI compared with the Standard of Care (SoC) for buprenorphine induction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Open\u2010label, two\u2010arm, randomized controlled non\u2010inferiority trial. The induction period lasted 7\u00a0days, after which all participants continued buprenorphine\u2010based OAMT as routine care. Follow\u2010up assessments were done at one week and one month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings<\/jats:title>\n                    <jats:p>Addiction treatment center, Chandigarh, India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Adults with opioid use disorder (OUD) meeting ICD\u201011 (\n                      <jats:italic>International Classification of Diseases<\/jats:italic>\n                      , 11th Revision) criteria, recruited between December 2023 and August 2024. A total of 138 participants were randomized (SoC\u2009=\u200970; TABI\u2009=\u200968). The mean age of participants was 28.2\u00a0years. Most participants were male (98.55%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>SoC involved supervised in\u2010person buprenorphine induction for three days. TABI consisted of in\u2010person induction on Day 1, followed by telemedicine\u2010based follow\u2010ups for Days 2\u20136. In\u2010person review on Day 7 in both arms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Primary outcome: treatment retention at one week, using a 15% non\u2010inferiority margin. Secondary outcomes: abstinence from illicit opioids, withdrawal symptoms, cravings, quality of life, satisfaction, therapeutic alliance and medication adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>The one\u2010week retention rate was 75.71% in the SoC group and 82.35% in the TABI group, with an absolute difference of 6.64% [95% confidence interval (CI)\u2009=\u2009\u22126.88% to 20.16%]. The lower limit of the 95% confidence interval for the difference (\u22126.88%) is above the pre\u2010specified non\u2010inferiority margin, confirming the non\u2010inferiority of TABI compared with SoC. Both groups showed statistically significant improvements in withdrawal symptoms, cravings and quality of life over time, with no statistically significant group differences. Patient satisfaction, therapeutic relationships, adherence and side effects were comparable between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This randomized controlled trial found that telemedicine\u2010assisted buprenorphine induction was non\u2010inferior to standard care for one\u2010week retention in treatment among adults with opioid use disorder. As such, it offers a patient\u2010centred alternative to standard care and has the potential to reduce treatment barriers and improve access in resource\u2010limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.70269","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:28:54Z","timestamp":1764548934000},"page":"883-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Telemedicine\u2010assisted buprenorphine induction versus standard of care: A randomized controlled non\u2010inferiority trial"],"prefix":"10.1111","volume":"121","author":[{"given":"Harpreet S.","family":"Dhillon","sequence":"first","affiliation":[{"name":"Drug Deaddiction and Treatment Center, Department of Psychiatry Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0988-7694","authenticated-orcid":false,"given":"Abhishek","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Drug Deaddiction and Treatment Center, Department of Psychiatry Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Naik","sequence":"additional","affiliation":[{"name":"Drug Deaddiction and Treatment Center, Department of Psychiatry Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subodh","family":"Nanjayya","sequence":"additional","affiliation":[{"name":"Drug Deaddiction and Treatment Center, Department of Psychiatry Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Verma","sequence":"additional","affiliation":[{"name":"Drug Deaddiction and Treatment Center, Department of Psychiatry Postgraduate Institute of Medical Education and Research  Chandigarh India"},{"name":"Department of Psychology Panjab University  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-5984","authenticated-orcid":false,"given":"Debasish","family":"Basu","sequence":"additional","affiliation":[{"name":"Drug Deaddiction and Treatment Center, Department of Psychiatry Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"24","article-title":"Global Status Report on alcohol and health and treatment of substance use disorders","volume":"13","author":"Sawin J","year":"2024","journal-title":"Renew Energy World"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32229-9"},{"key":"e_1_2_9_4_1","volume-title":"Magnitude of substance use in India \u2010 Google Scholar","author":"Ambekar A","year":"2019"},{"key":"e_1_2_9_5_1","unstructured":"World Health Organization. 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