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Evidence suggests that such changes could increase the risk of cannabis use and related harms, and could influence patterns of use of other substances among adolescents. This study measured the potential impact of these legislative changes on adolescent substance\u2010related hospital admissions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>An interrupted time\u2010series study to assess the impact of cannabis legalisation on substance\u2010related hospitalisations using anonymised admission records from the Thai Health Information Portal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Nationwide study in Thailand spanning from 1 October 2016 to 30 September 2023, with 9 June 2022 marking cannabis legalisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants\/cases<\/jats:title>\n                    <jats:p>Adolescents aged 10\u201319\u2009years in Thailand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Based on International Classification of Diseases, 10th Revision diagnostic codes, hospitalisation records were classified as relevant or irrelevant to each of eight predefined substance categories: stimulants (excluding cocaine), alcohol, cannabis, sedatives (including opioids and narcotics), volatile solvents, nicotine, hallucinogens and cocaine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>There were an additional 25.5 weekly cannabis\u2010related hospitalisations (95% prediction interval = 23.5\u201327.2) compared with counterfactual predictions, resulting in 1762 excess cases over the 68\u2010week post\u2010legalisation period. Statistically significant excess admissions were also observed for stimulants, nicotine, volatile solvents and hallucinogens, corresponding to additional admissions of 9.1, 1.4, 0.5 and 0.5 per week, respectively (95% prediction intervals = 0.3\u201315.4, 0.4\u20132.1, 0.3\u20130.7 and 0.2\u20130.7, respectively). No statistically significant changes were observed for alcohol\u2010, sedative\u2010 or cocaine\u2010related hospitalisations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cannabis legalisation in Thailand was followed by a marked rise in adolescent hospitalisations related to cannabis, alongside an increase in stimulant\u2010, nicotine\u2010, volatile solvent\u2010 and hallucinogen\u2010related hospitalizations. These findings highlight the potential unintended consequences of cannabis legalisation in Thailand and underscore the need for preventive strategies to reduce adolescent exposure and related harm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/add.70484","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:20:04Z","timestamp":1779409204000},"page":"2768-2779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Change of substance\u2010related hospitalisation in adolescents after cannabis legalisation in Thailand in 2022"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9265-3385","authenticated-orcid":false,"given":"Sirada","family":"Puetpaiboon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-7409","authenticated-orcid":false,"given":"Songyos","family":"Rajborirug","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vorthunju","family":"Nakhonsri","sequence":"additional","affiliation":[{"name":"Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chumpol","family":"Ngamphiw","sequence":"additional","affiliation":[{"name":"Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peerapat","family":"Khunkham","sequence":"additional","affiliation":[{"name":"Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sissades","family":"Tongsima","sequence":"additional","affiliation":[{"name":"Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Watcharapot","family":"Janpoung","sequence":"additional","affiliation":[{"name":"Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virasakdi","family":"Chongsuvivatwong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.47626\/2237-6089-2021-0263"},{"key":"e_1_2_10_3_1","unstructured":"Cannabis legalization world map: March 2025 updated [Internet].Cannabusinessplans.com.2025[cited 2025 Aug 4]. 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