{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:16Z","timestamp":1787013796036,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T00:00:00Z","timestamp":1359504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Along with conventional periodontal surgical therapy, local delivery of antibiotics may provide more effective treatment in smokers by targeting tissue\u2010invasive bacteria. The aim of this randomized, placebo\u2010controlled, double\u2010masked clinical trial was to evaluate the adjunctive effects of subgingivally delivered 0.5% azithromycin (\n                      <jats:styled-content style=\"fixed-case\">AZM<\/jats:styled-content>\n                      ) as an adjunct to scaling and root planing (\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      ) in the treatment of chronic periodontitis in smokers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four patients were randomized and categorized into two treatment groups: Group 1\u00a0\u2013\u00a026 subjects who received (SRP) plus placebo gel and Group 2\u00a0\u2013\u00a028 subjects who received (SRP) plus 0.5% azithromycin. Clinical parameters were recorded at baseline, 3, 6 and 9\u00a0months. They included Plaque Index (PI), modified Sulcus Bleeding Index (\n                      <jats:styled-content style=\"fixed-case\">mSBI<\/jats:styled-content>\n                      ), probing depth (PD) and clinical attachment level (CAL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Azithromycin resulted in significant improvements. A single application of AZM resulted in attachment gain at 9\u00a0months of 2.44\u00a0\u00b1\u00a00.64\u00a0mm as compared to 0.18\u00a0\u00b1\u00a00.68\u00a0mm for the placebo. Similarly, pocket depth and PI were significantly reduced but no change in the\n                      <jats:styled-content style=\"fixed-case\">mSBI<\/jats:styled-content>\n                      was noted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      When compared to the placebo, the adjunctive use of 0.5%\n                      <jats:styled-content style=\"fixed-case\">AZM<\/jats:styled-content>\n                      resulted in significant improvement in clinical outcome in the treatment of chronic periodontitis among smokers.\n                    <\/jats:p>\n                  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