{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:38:06Z","timestamp":1791171486338,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Simvastatin (\n                      <jats:styled-content style=\"fixed-case\">SMV<\/jats:styled-content>\n                      ) is a specific competitive inhibitor of 3\u2010hydroxy\u20102\u2010methyl\u2010glutaryl coenzyme A reductase. Statins have recently been shown to promote bone formation. This study was designed to investigate the effectiveness of\n                      <jats:styled-content style=\"fixed-case\">SMV<\/jats:styled-content>\n                      1.2% in an indigenously prepared biodegradable controlled release gel as an adjunct to scaling and root planing (\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      ) in the treatment of smokers with chronic periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty patients were categorized into two treatment groups: SRP plus SMV 1.2% and SRP plus placebo. Clinical parameters were recorded at baseline and at 3, 6 and 9\u00a0months; they included modified sulcus bleeding index (\n                      <jats:styled-content style=\"fixed-case\">mSBI<\/jats:styled-content>\n                      ), probing depth (PD) and clinical attachment level (CAL). At baseline, after 6\u00a0months and 9\u00a0months, radiologic assessment of intrabony defect (IBD) fill was done using computer\u2010aided software.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean probing depth reduction and mean clinical attachment level gain was greater in the\n                      <jats:styled-content style=\"fixed-case\">SMV<\/jats:styled-content>\n                      group than the placebo group at all visits. Furthermore, significantly greater mean percentage of bone fill was found in the\n                      <jats:styled-content style=\"fixed-case\">SMV<\/jats:styled-content>\n                      group (32.37\u00a0\u00b1\u00a010.23%) compared to the placebo (4.18\u00a0\u00b1\u00a05.39%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      There was a greater decrease in\n                      <jats:styled-content style=\"fixed-case\">mSBI<\/jats:styled-content>\n                      and PD and more CAL gain with significant IBD fill at sites treated with SRP plus locally delivered SMV in smokers with chronic periodontitis.\n                    <\/jats:p>\n                  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