{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T08:40:14Z","timestamp":1716453614183},"reference-count":32,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T00:00:00Z","timestamp":1389830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Today, and looking to the future, scientific discoveries from cellular, developmental and molecular biology inform our understanding of cell, tissue and organ morphogenesis as exemplified in skin, bone, cartilage, dentine, enamel, muscle, nerve and many organs such as salivary glands and teeth. Present day biomedical science yields principles for the biomimetic design and fabrication of cells, tissues and organs. Bioengineering has become a strategy that can \u2018mimic\u2019 biological processes, and inform clinical procedures for tissue and organ replacements. The future of regenerative craniofacial biology holds enormous promise for the diagnosis and treatment of congenital birth defects, traumatic injuries, degenerative chronic diseases as well as for Mendelian single gene and complex multigene diseases and disorders. The past 50\u00a0years have heralded the completion of the human genome and the introduction of \u2018personalized medicine and dentistry\u2019, the utilization of stem cell therapy for an array of diseases and disorders, the \u2018proof of principle\u2019 to reverse select inherited diseases such as anhidrotic ectodermal dysplasia (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>), and the fruits from interdisciplinary research drawn from the diverse biomedical sciences. Looking to the future, we can readily anticipate as major goals to emphasize the clinician's role in identifying clinical phenotypes that can lead to differential diagnosis, and rejuvenate missing or damaged tissues by establishing processes for the utilization of gene, cell and\/or protein therapies. The future is replete with remarkable opportunities to enhance clinical outcomes for congenital as well as acquired craniofacial malformations. Clinicians play a pivotal role because critical thinking and sound clinical acumen substantially improve diagnostic precision and thereby clinical health outcomes.<\/jats:p>","DOI":"10.1111\/adj.12105","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T01:14:54Z","timestamp":1389921294000},"page":"186-190","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The future of research in craniofacial biology and what this will mean for oral health professional education and clinical practice"],"prefix":"10.1111","volume":"59","author":[{"given":"HC","family":"Slavkin","sequence":"first","affiliation":[{"name":"Center for Craniofacial Molecular Biology Ostrow School of Dentistry The University of Southern California California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,16]]},"reference":[{"key":"e_1_2_4_2_1","volume-title":"An evaluation and assessment of the state of the science: congenital and acquired craniofacial malformations","author":"Pruzansky S","year":"1982"},{"key":"e_1_2_4_3_1","volume-title":"Symposium on diagnosis and treatment of craniofacial anomalies","author":"Converse JM","year":"1979"},{"key":"e_1_2_4_4_1","volume-title":"Cleft lip and palate: surgical, dental and speech aspects","author":"Grabb WC","year":"1971"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197111000-00002"},{"key":"e_1_2_4_6_1","first-page":"287","volume-title":"Congenital anomalies of the ear, nose and throat","author":"Gorlin RJ","year":"1997"},{"key":"e_1_2_4_7_1","volume-title":"Birth of a discipline: craniofacial biology","author":"Slavkin HC","year":"2012"},{"key":"e_1_2_4_8_1","unstructured":"Craniofacial Australia. URL: \u2018http:\/\/www.craniofacial.com.au\/aboutus.htmlAccessed 2 May 2013."},{"key":"e_1_2_4_9_1","unstructured":"Australian Institute of Health and Welfare.Oral health and dental care in Australia. URL: \u2018http:\/\/www.aihw.gov.au\/publication-detail\/id=10737420710&tab=2\u2019. Accessed 2 May 2013."},{"key":"e_1_2_4_10_1","unstructured":"US Department of Health and Human Services.Oral health in America: a report of the Surgeon General.National Institute of Dental and Craniofacial Research National Institutes of Health and US Department of Health and Human Services Rockville Maryland 2000."},{"key":"e_1_2_4_11_1","unstructured":"Australian Bureau of Statistics. Demographics of Australia. URL:http:\/\/abs.gov.au. Accessed 3 October 2013."},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0351"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2012.76.1.tb05231.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0907175"},{"key":"e_1_2_4_15_1","volume-title":"The $1,000 Genome: the revolution in DNA sequencing and the new era of personalized medicine","author":"Davies K","year":"2010"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12100"},{"key":"e_1_2_4_17_1","first-page":"98","article-title":"Emerging opportunities for the next generation of dental implants","volume":"28","author":"Shi S","year":"2009","journal-title":"Dent Today"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32862"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm861"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2897"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12156."},{"key":"e_1_2_4_22_1","unstructured":"NIFA\u2010NSF Phenomics Workshop Report.Phenomics: genotype to phenotype.National Science Foundation Washington DC USA.2011."},{"key":"e_1_2_4_23_1","volume-title":"Craniosynostosis: diagnosis, evaluation and management","author":"Cohen MM","year":"2000"},{"key":"e_1_2_4_24_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/oso\/9780195306910.003.0044","volume-title":"Inborn Errors of Development","author":"Wilkie AOM","year":"2008"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61854-5"},{"key":"e_1_2_4_26_1","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/j.0022-0337.2004.68.11.tb03859.x","article-title":"Reforming dental health professions education: a white paper","volume":"48","author":"DePaola D","year":"2004","journal-title":"J Dent Educ"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511420435"},{"key":"e_1_2_4_28_1","first-page":"6","article-title":"The answer lies in the genome","volume":"14","author":"Slavkin HC","year":"2012","journal-title":"Global Health Nexus"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_4_30_1","first-page":"276","volume-title":"Dental Horizons: Essentials of Oral Health","author":"Slavkin HC","year":"2011"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2008.00448.x"},{"key":"e_1_2_4_32_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195300406.001.0001","volume-title":"Perspectives on the face","author":"Cohen MM","year":"2006"},{"key":"e_1_2_4_33_1","unstructured":"Preface.Report of the National Institute of Dental and Craniofacial Research Genetics Workgroup. Genetics and Craniofacial and Dental Anomalies.Bethesda Maryland USA. 14\u201316 November1999."}],"container-title":["Australian Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadj.12105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adj.12105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T08:07:57Z","timestamp":1716451677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adj.12105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,16]]},"references-count":32,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/adj.12105"],"URL":"https:\/\/doi.org\/10.1111\/adj.12105","archive":["Portico"],"relation":{},"ISSN":["0045-0421","1834-7819"],"issn-type":[{"value":"0045-0421","type":"print"},{"value":"1834-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,16]]},"assertion":[{"value":"2014-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}