{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:30:29Z","timestamp":1783441829303,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the endothelial function, systemic inflammatory biomarkers and subgingival microbial profile associations in patients with and without periodontal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four patients, half with chronic moderate to severe periodontitis (cases) and half gingivitis and incipient periodontitis (controls) were recruited. Anthropometric, clinical, biochemical parameters, endothelial function, subgingival microbiota, and eight plasma biomarkers of cardiovascular disease were assessed in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups were comparable in anthropometric parameters, blood pressure, and number of positive metabolic syndrome components. Univariate analyses demonstrated significantly higher plasma levels of E\u2010selectin (64.5\u00a0\u00b1\u00a030.9 vs 43.8\u00a0\u00b1\u00a022.2; P\u00a0=\u00a00.026) and myeloperoxidase (<jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>) (103\u00a0\u00b1\u00a0114.5 vs 49.1\u00a0\u00b1\u00a035.6; P\u00a0=\u00a00.032) in cases than controls. In addition, significantly higher levels of E\u2010selectin, <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 were found in periodontitis patients after adjustment by age and waist circumference. Red complex microorganisms were more frequently detected by culture and polymerase chain reaction in patients with severe to moderate periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subgingival red complex bacteria and important cardiovascular risk markers were increased in untreated chronic moderate to severe periodontitis cases. Periodontitis seems to be associated with systemic inflammation that could increase the risk of cardiovascular events. The causal relation between periodontal infections and cardiovascular disease requires further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12139","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T21:42:25Z","timestamp":1391550145000},"page":"29-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis: a case control study"],"prefix":"10.1111","volume":"59","author":[{"given":"JH","family":"Ram\u00edrez","sequence":"first","affiliation":[{"name":"Periodontal Medicine Research Group Dentistry School Universidad del Valle Cali Colombia"},{"name":"School of Health Sciences Universidad del Valle Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Parra","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Basic Sciences Universidad del Valle Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Periodontal Medicine Research Group Dentistry School Universidad del Valle Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RM","family":"Arce","sequence":"additional","affiliation":[{"name":"Department of Periodontics Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Periodontal Medicine Research Group Dentistry School Universidad del Valle Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ariza","sequence":"additional","affiliation":[{"name":"School of Health Sciences Universidad del Valle Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Contreras","sequence":"additional","affiliation":[{"name":"Periodontal Medicine Research Group Dentistry School Universidad del Valle Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2005.03.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.06.037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.101535"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.03.037"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063186"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1366.032"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000129769.17895.F0"},{"key":"e_1_2_8_10_1","volume-title":"III Estudio Nacional en Salud Bucal (ENSAB III)","author":"Tovar SZE","year":"1999"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01746-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1986.tb00318.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1996.tb00180.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2008.12.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100196"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/760837"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600806"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060129"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280102.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000078603.90302.4A"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.10.002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.12.1694"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.09.059"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.12.003"},{"key":"e_1_2_8_26_1","first-page":"157","article-title":"Colombian study to assess the use of noninvasive determination of endothelium\u2010mediated vasodilatation (CANDEV)","volume":"8","author":"Accini JL","year":"2001","journal-title":"Normal values and factors associated. Endothelium"}],"container-title":["Australian Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadj.12139","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adj.12139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:30:00Z","timestamp":1696501800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adj.12139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,4]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/adj.12139"],"URL":"https:\/\/doi.org\/10.1111\/adj.12139","archive":["Portico"],"relation":{},"ISSN":["0045-0421","1834-7819"],"issn-type":[{"value":"0045-0421","type":"print"},{"value":"1834-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,4]]},"assertion":[{"value":"2013-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}