{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T13:51:15Z","timestamp":1774792275121,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T00:00:00Z","timestamp":1401062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Localized aggressive periodontitis (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP) is an infectious periodontal disease which generally affects young people. Recent data suggest the involvement of different bacterial species in different populations. The causative bacterial species in Israel has never been identified despite a high prevalence of <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP in this population. The objectives of this study were to characterize the bacterial microbiota of periodontal pockets within an Israeli <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP population who were also clinically assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP patients (test) and 12 chronic periodontitis patients (control) were examined. Bacterial samples were collected from periodontal pockets and analysed by both culture and polymerase chain reaction techniques. Mann\u2013Whitney U test and chi\u2010square test were used to compare results between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher levels of <jats:italic>Parvimonas micra<\/jats:italic> (&gt;10<jats:sup>6<\/jats:sup>), <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (&gt;10<jats:sup>5<\/jats:sup>), <jats:italic>Fusobacterium nucleatum\/F. periodonticum<\/jats:italic> (&gt;10<jats:sup>6<\/jats:sup>), and <jats:italic>Tannerella forsythia<\/jats:italic> (levels of 10<jats:sup>5<\/jats:sup> to 10<jats:sup>6<\/jats:sup> bacteria) were detected in the <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP group compared to the control (p &lt; 0.05), while levels of <jats:italic>Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Prevotella intermedia<\/jats:italic> were higher in the <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The characteristic periodontal bacterial flora of <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP patients in Israel is mainly comprised of <jats:italic>P. micra, A. actinomycetemcomitans, F. nucleatum\/F. periodonticum<\/jats:italic> and <jats:italic>T. forsythia<\/jats:italic>. Similar population based studies of each population will improve the quality of treatment of <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP when individual sampling is not possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12165","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T03:57:13Z","timestamp":1401163033000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical and microbiological characterization of localized aggressive periodontitis: a cohort study"],"prefix":"10.1111","volume":"59","author":[{"given":"O","family":"Oettinger\u2010Barak","sequence":"first","affiliation":[{"name":"Melbourne Dental School The University of Melbourne Parkville Victoria Australia"},{"name":"Oral Ecology and Microbiology, Faculty of Dental Medicine The Hebrew University of Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MN","family":"Sela","sequence":"additional","affiliation":[{"name":"Oral Ecology and Microbiology, Faculty of Dental Medicine The Hebrew University of Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sprecher","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory Rambam Health Care Campus Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EE","family":"Machtei","sequence":"additional","affiliation":[{"name":"School of Graduate Dentistry Department of Periodontology Rambam Health Care Campus Haifa Israel"},{"name":"School of Dental Medicine Harvard Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.4.243"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.2.93"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.8.2988-2997.1996"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.1.52"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.9.820"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1986.57.2.94"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb01626.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.3.275"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.6.352"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00339.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01254.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345850640050201"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00777.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027006417.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.912"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb01689.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.4.592"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1983.54.12.707"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1976.47.7.373"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1977.tb00114.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.727-752.2001"},{"key":"e_1_2_9_24_1","first-page":"89","article-title":"Actinobacillus actinomycetemcomitans and black\u2010pigmented bacteroides in advanced periodontitis in man. 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