{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T22:50:27Z","timestamp":1775170227630,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methotrexate (<jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>) is the primary drug used in the management of rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) and other immune\u2010mediated inflammatory diseases. <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> is a strong immunosuppressive agent and has been reported to cause iatrogenic immunodeficiency\u2010associated lymphoproliferative disorders (<jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>s). Stomatitis caused by <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\u2010related cytotoxicity may occur, but gingival <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>s are rare. In this article we present a case of gingival <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content> in a 60\u2010year\u2010old male with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. The local findings of the gingival ulceration and alveolar bone exposure were similar to those of bisphosphonate\u2010related osteonecrosis of the jaw. However, he had never received bisphosphonate therapy. The biopsy specimen of the gingival lesion was diagnosed as diffuse large B\u2010cell lymphoma with Epstein\u2010Barr virus positivity. Immediate withdrawal of <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> resulted in marked remission of the <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/adj.12235","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T11:29:20Z","timestamp":1412940560000},"page":"408-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Methotrexate\u2010related lymphoproliferative disorder arising in the gingiva of a patient with rheumatoid arthritis"],"prefix":"10.1111","volume":"60","author":[{"given":"N","family":"Horie","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"2237","article-title":"Methotrexate\u2010related Epstein\u2010Barr virus\u2010associated lymphoproliferative disorder occurring in the gingiva of a patient with rheumatoid arthritis","volume":"6","author":"Ishida M","year":"2013","journal-title":"Int J 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