{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:04:38Z","timestamp":1792512278659,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002385","name":"Ministry of Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of this study was to investigate malondialdehyde (MDA<\/jats:styled-content>), superoxide dismutase (SOD<\/jats:styled-content>) and melatonin levels in the gingival crevicular fluid (GCF<\/jats:styled-content>) of patients with chronic periodontitis (CP<\/jats:styled-content>) and generalized aggressive periodontitis (GA<\/jats:styled-content>gP) as biomarkers for oxidative stress.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study comprised 65 subjects: 15 healthy individuals, 25 CP<\/jats:styled-content> patients and 25 GA<\/jats:styled-content>gP patients. Plaque index, gingival index, pocket depth, clinical attachment level measurements and GCF<\/jats:styled-content> samples were obtained from all subjects. MDA<\/jats:styled-content>, SOD<\/jats:styled-content> and melatonin levels were determined utilizing enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec>Results<\/jats:title>GCF<\/jats:styled-content>\u2010MDA<\/jats:styled-content> levels were significantly higher in the GA<\/jats:styled-content>gP group compared to the CP<\/jats:styled-content> and control groups (p < 0.001) and significantly higher in the CP<\/jats:styled-content> group than the C group (p < 0.001). SOD<\/jats:styled-content> and melatonin GCF<\/jats:styled-content> levels were significantly higher in the control than the GA<\/jats:styled-content>gP and CP<\/jats:styled-content> groups (p < 0.05), and significantly lower in the GA<\/jats:styled-content>gP than the CP<\/jats:styled-content> group (p < 0.05). The CP<\/jats:styled-content> group demonstrated a significant negative correlation between GCF<\/jats:styled-content>\u2010MDA<\/jats:styled-content> and melatonin concentrations. A positive correlation was observed between SOD<\/jats:styled-content> and CAL<\/jats:styled-content> in the CP<\/jats:styled-content> group and PD<\/jats:styled-content> in the GA<\/jats:styled-content>gP group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>MDA<\/jats:styled-content>, melatonin and SOD<\/jats:styled-content> could be considered as biomarkers for oxidative stress in periodontal diseases and might be useful diagnostic aids in distinguishing CP<\/jats:styled-content> and GA<\/jats:styled-content>gP patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12294","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T16:44:53Z","timestamp":1420821893000},"page":"53-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Malondialdehyde, superoxide dismutase and melatonin levels in gingival crevicular fluid of aggressive and chronic periodontitis 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