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The reduction of the biofilm is important in the management of the disease. This study compares periodontopathogen levels following the treatment of chronic periodontitis using Er:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser (<jats:styled-content style=\"fixed-case\">ERL<\/jats:styled-content>) debridement and mechanical scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a split\u2010mouth design, two quadrants were randomly allocated for treatment. Two hundred and fifty\u2010two subgingival plaque samples were collected from 21 patients, before treatment (baseline) and at 6 and 12 weeks post\u2010therapy. Multiplex <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> was used to determine relative levels of <jats:italic>Porphyromonas gingivalis (Pg)<\/jats:italic>,<jats:italic> Treponema denticola (Td)<\/jats:italic>,<jats:italic> Tannerella forsythensis (Tf)<\/jats:italic>, and <jats:italic>Aggregatibacter actinomycetemcomitans (Aa)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Tf<\/jats:italic> and <jats:italic>Pg<\/jats:italic> were significantly reduced post\u2010treatment for both <jats:styled-content style=\"fixed-case\">ERL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">ERL<\/jats:styled-content> treatment resulted in a reduction of <jats:italic>Td<\/jats:italic> at 12 weeks. Following <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> treatment <jats:italic>Aa<\/jats:italic> was significantly reduced at 12 weeks. No statistically significant difference was seen when treatments were compared at 6 and 12 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A comparable reduction in the level of the four periodontal pathogens assayed was achieved with Er:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser debridement and mechanical scaling and root planing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12306","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T06:53:03Z","timestamp":1422514383000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Periodontopathogen levels following the use of an Er:YAG laser in the treatment of chronic periodontitis"],"prefix":"10.1111","volume":"61","author":[{"given":"TJ","family":"Milne","sequence":"first","affiliation":[{"name":"Sir John Walsh Research Institute School of Dentistry University 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