{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:30Z","timestamp":1787237730828,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Abbott Healthcare Pvt Ltd","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Curcumin has anti\u2010inflammatory properties. The aim of this study was to compare interleukin\u20101\u03b2 (\n IL<\/jats:styled-content>\n \u20101\u03b2) and chemokine (C\u2010C motif) ligand 28 (\n CCL<\/jats:styled-content>\n 28) levels following a topical application of curcumin (\n CRM<\/jats:styled-content>\n ), chlorhexidine (\n CHX<\/jats:styled-content>\n ) and chlorhexidine\u2010metronidazole (\n CHX<\/jats:styled-content>\n \u2010\n MTZ<\/jats:styled-content>\n ) in an experimental gingivitis human model.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Sixty systemically healthy selected subjects were randomly assigned to one of three topical antigingivitis gels. Each gel was applied twice daily for 10\u00a0minutes as the sole method of oral hygiene for 29\u00a0days on the test quadrant only. Modified gingival index (\n MGI<\/jats:styled-content>\n ), plaque index (\n PI<\/jats:styled-content>\n ), bleeding on probing (\n BOP<\/jats:styled-content>\n ) and probing depth (\n PD<\/jats:styled-content>\n ) were assessed at baseline, 29\u00a0days and 60\u00a0days. Estimation of\n IL<\/jats:styled-content>\n \u20101\u03b2 and\n CCL<\/jats:styled-content>\n 28 levels in gingival crevicular fluid was done at baseline and at 29\u00a0days.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The increase of\n IL<\/jats:styled-content>\n \u20101\u03b2 in the\n CRM<\/jats:styled-content>\n (14.52\u00a0\u00b1\u00a016.6\u00a0pg\/ml) and\n CHX<\/jats:styled-content>\n \u2010\n MTZ<\/jats:styled-content>\n (31.63\u00a0\u00b1\u00a015.96) groups was significantly less than that of the\n CHX<\/jats:styled-content>\n group (70.55\u00a0\u00b1\u00a038.81). Similar results were also observed for\n CCL<\/jats:styled-content>\n 28 (\n CRM<\/jats:styled-content>\n : 8.12\u00a0\u00b1\u00a08.78\u00a0pg\/ml;\n CHX<\/jats:styled-content>\n \u2010\n MTZ<\/jats:styled-content>\n : 12.81\u00a0\u00b1\u00a018.68;\n CHX<\/jats:styled-content>\n : 41.15\u00a0\u00b1\u00a022.82). All groups had a significant increase in\n MGI<\/jats:styled-content>\n ,\n PI<\/jats:styled-content>\n and\n BOP<\/jats:styled-content>\n at 29\u00a0days.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The anti\u2010inflammatory potential of topical curcumin was similar to\n CHX<\/jats:styled-content>\n \u2010\n MTZ<\/jats:styled-content>\n but superior to\n CHX<\/jats:styled-content>\n in affecting\n IL<\/jats:styled-content>\n \u20101\u03b2 and\n CCL<\/jats:styled-content>\n 28 levels.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/adj.12340","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T03:10:11Z","timestamp":1438139411000},"page":"317-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of curcumin on crevicular levels of\n IL<\/scp>\n \u20101\u03b2 and\n CCL<\/scp>\n 28 in experimental gingivitis"],"prefix":"10.1111","volume":"60","author":[{"given":"SJ","family":"Pulikkotil","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry School of Dentistry International Medical University Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Periodontology Vananchal Dental College and Hospital Garhwa Jharkhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"issue":"29","key":"e_1_2_8_2_1","first-page":"122","article-title":"Periodontal diseases in Asia and Oceania","volume":"2002","author":"Corbet EF","year":"2000","journal-title":"Periodontol"},{"issue":"62","key":"e_1_2_8_3_1","first-page":"7","article-title":"Periodontology: past, present, perspectives","volume":"2013","author":"Slots 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