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This systematic review and meta\u2010analysis of the existing epidemiological studies was conducted to determine if there is a correlation between oral lichen planus and hepatitis C virus infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the association between hepatitis C virus and oral lichen planus by conducting a systematic review and meta\u2010analysis of case\u2010control studies that examined the prevalence of anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibodies in the serum of cases and controls. We searched PubMed, Embase and The Cochrane Library databases from 2005 to January 2015. Associations were measured using random\u2010effect odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) combined with 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen eligible studies, encompassing 1807 cases of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and 2519 controls, were retrieved and included in this review. The summary estimate <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for all studies was 6.07 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.73\u201313.48), showing a statistically significant difference in the proportion of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seropositivity among oral lichen planus patients, compared with controls and substantial heterogeneity between studies (<jats:italic>I<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>= 65%) as a result of a variety of geographical distributions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association of hepatitis C virus infection with oral lichen planus emphasizes the importance of hepatitis C virus screening in oral lichen planus patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12382","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T07:29:03Z","timestamp":1445066943000},"page":"282-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Hepatitis C virus infections in oral lichen planus: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"61","author":[{"given":"NA","family":"Alaizari","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Sciences Faculty of Dentistry Al\u2010Farabi Colleges Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SA","family":"Al\u2010Maweri","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Sciences Faculty of Dentistry Al\u2010Farabi Colleges Riyadh Saudi 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