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Clinical concerns are primarily related to achieving adequate levels of disinfection as \u2018aggressive\u2019 instrumentation is contraindicated and hence there exists a much greater reliance on endodontic irrigants and medicaments. The open apex has also presented obturation difficulties, notably in controlling length. Long\u2010term apexification procedures with calcium hydroxide have proven to be successful in retaining many of these immature infected teeth but due to their thin dentinal walls and perceived problems associated with long\u2010term placement of calcium hydroxide, they have been found to be prone to cervical fracture and subsequent tooth loss. In recent years there has developed an increasing interest in the possibility of \u2018regenerating\u2019 pulp tissue in an infected immature tooth. It is apparent that although the philosophy and hope of \u2018regeneration\u2019 is commendable, recent histologic studies appear to suggest that the calcified material deposited on the canal wall is bone\/cementum rather than dentine, hence the absence of pulp tissue with or without an odontoblast layer.<\/jats:p>","DOI":"10.1111\/adj.12401","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:48:38Z","timestamp":1456793318000},"page":"95-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Management of incompletely developed teeth requiring root canal treatment"],"prefix":"10.1111","volume":"61","author":[{"given":"SC","family":"Harlamb","sequence":"first","affiliation":[{"name":"Private Practice Burwood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1992.tb00228.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2004.00284.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356109043395"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/etp.12040"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(72)80042-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2008.00225.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2008.00223.x"},{"key":"e_1_2_5_9_1","first-page":"167","article-title":"Effect of drying on viability of periodontal membrane","volume":"85","author":"Soder PO","year":"1977","journal-title":"Scand J Dent Res"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2001.017002093.x"},{"key":"e_1_2_5_11_1","first-page":"391","article-title":"Surgical treatment of ankylosed and infrapositioned reimplanted incisors in adolescents","volume":"92","author":"Malmgren B","year":"1984","journal-title":"Scand J Dent Res"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-9657.2012.01125.x","article-title":"IADT guidelines for the management of traumatic dental injuries","volume":"28","author":"International Association of Dental Traumatology","year":"2012","journal-title":"Dent Traumatol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1995.tb00463.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00132.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-4469.2001.00001.x"},{"key":"e_1_2_5_16_1","unstructured":"International Association of Dental Traumatology.Dental Trauma Guide: 2012. 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