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The aim of this study was to compare clinical outcomes for patients with moderate\u2010advanced chronic periodontitis treated with: scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> with amoxicillin and metronidazole (A+M), <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> with Azithromycin (Az).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010seven non\u2010smokers with generalized moderate to advanced chronic periodontitis were divided into three treatment groups: <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>, A+M and Az. Patients received the medications after the last <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> session and were reviewed three months later. Changes in clinical parameters were compared between the groups. Separate analyses were executed for: \u2018all sites\u2019, \u2018molar sites\u2019, \u2018sites with different <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> severities\u2019 and \u2018number of sites with shallow, moderate and deep <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three groups exhibited improvements in most clinical parameters. At three months, A+M showed a higher reduction in <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> compared to Az in the \u2018all sites analysis\u2019. Molars exhibited better reduction in <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> with A+M than <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>. Pocket depth of the 4\u20136 mm category reduced more in the A+M than <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>. A+M experienced a higher increase in the number of sites with <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> 1\u20133 mm than Az.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adjunctive systemic antibiotics in the initial phase of treatment may result in improved clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12415","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T21:41:12Z","timestamp":1454449272000},"page":"469-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of adjunctive azithromycin and amoxicillin\/metronidazole for patients with chronic periodontitis: preliminary randomized control trial"],"prefix":"10.1111","volume":"61","author":[{"given":"A","family":"Saleh","sequence":"first","affiliation":[{"name":"Oral Health Centre of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rincon","sequence":"additional","affiliation":[{"name":"Oral Health Centre of Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tan","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital Subiaco Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Firth","sequence":"additional","affiliation":[{"name":"Centre for Applied Statistics School of Mathematics and Statistics The University of Western Australia Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.38"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.322"},{"key":"e_1_2_8_4_1","first-page":"7","article-title":"Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT)","volume":"1","author":"Lang NP","year":"2003","journal-title":"Oral Health Prev Dent"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02024.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01309.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01297.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1978.tb01918.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb01034.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01271.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb01673.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.11.692"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070072"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01607.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01766.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01418.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080540"},{"key":"e_1_2_8_18_1","first-page":"710","article-title":"Are there specific benefits of amoxicillin plus metronidazole in aggregatibacter actinomycetemcomitans\u2010associated periodontitis? 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