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Moreover, intraoral aging affects the biologic properties of materials. The aim of this review is to present the currently identified major adverse effects of the metallic and polymeric components found in orthodontic appliances and materials. Corrosion in metallic orthodontic attachments releases metal ions, mainly iron, chromium, and nickel. The latter has received the greatest attention because of its reported potential for an allergic response. The formation of an oxide layer may inhibit the outward movement of ions, thereby acting as an obstacle for release. Titanium alloys have superior corrosion resistance than stainless steel. The efficiency of polymerisation is considered an essential property for all polymers. A poor polymer network is susceptible to the release of biologically reactive substances, such as bisphenol\u2010A (\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    ), which is capable of inducing hormone\u2010related effects. The close proximity of a light\u2010curing tip to the adhesive, pumice prophylaxis after bonding, indirect irradiation and mouth rinsing during the first hour after bonding may decrease\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    release. The adverse effects of some orthodontic materials should be considered during material selection and throughout orthodontic treatment, in order to minimise possible undesirable implications.\n                  <\/jats:p>","DOI":"10.1111\/adj.12473","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T10:42:40Z","timestamp":1489488160000},"page":"20-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Adverse reactions to orthodontic materials"],"prefix":"10.1111","volume":"62","author":[{"given":"I","family":"Sifakakis","sequence":"first","affiliation":[{"name":"Department of Orthodontics School of Dentistry, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Eliades","sequence":"additional","affiliation":[{"name":"Clinic of Orthodontics and Paediatric Dentistry, Center of Dental Medicine, 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