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The first provides treatment in two phases; one of intervention during the mixed dentition (phase I) followed by a second definitive course of appliance treatment in early adolescence (phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>). The second approach involves providing a single course of comprehensive therapy during adolescence. The debate for and against early treatment is discussed alongside key, clinically relevant evidence related to Class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> division I malocclusions.<\/jats:p>","DOI":"10.1111\/adj.12478","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T14:42:40Z","timestamp":1489502560000},"page":"4-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Early Class <scp>II<\/scp> treatment"],"prefix":"10.1111","volume":"62","author":[{"given":"CA","family":"Brierley","sequence":"first","affiliation":[{"name":"Chesterfield Royal Hospital Chesterfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"DiBiase","sequence":"additional","affiliation":[{"name":"Kent &amp; Canterbury Hospital Canterbury Kent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PJ","family":"Sandler","sequence":"additional","affiliation":[{"name":"Chesterfield Royal Hospital Chesterfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Office for National Statistics.National children's dental health survey [Internet].2003[cited 2016 Feb 22]. 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