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The risks of orthodontic treatment include periodontal damage, pain, root resorption, tooth devitalization, temporomandibular disorder, caries, speech problems and enamel damage. These risks can be understood to arise from a synergy between treatment and patient factors. In general terms, treatment factors that can influence risk include appliance type, force vectors and duration of treatment whilst relevant patient factors are both biological and behavioural. Hence, the natural variation between orthodontic treatment plans and patients gives rise to variations in risk. A good understanding of these risks is required for clinicians to obtain informed consent before starting treatment as well as to reduce the potential for harm during treatment. After considering each of these risks, a conceptual framework is presented to help clinicians better understand how orthodontic risks arise and may therefore be mitigated.<\/jats:p>","DOI":"10.1111\/adj.12486","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T02:22:52Z","timestamp":1479694972000},"page":"86-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Potential risks of orthodontic therapy: a critical review and conceptual framework"],"prefix":"10.1111","volume":"62","author":[{"given":"M","family":"Wishney","sequence":"first","affiliation":[{"name":"Discipline of Orthodontics Faculty of Dentistry University of Sydney Sydney Australia"},{"name":"Dental Hospital Sydney South West Area Health Service Sydney 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