{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:53:36Z","timestamp":1774623216118,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Osteonecrosis of the jaw (<jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content>) is a serious complication of both radiation and antiresorptive therapies. This study aimed to determine how many patients have been treated for medication\u2010related osteonecrosis of the jaws (<jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content>) and osteoradionecrosis (<jats:styled-content style=\"fixed-case\">ORN<\/jats:styled-content>), and whether the number of diagnoses has decreased over time with improved awareness and preventative measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records at the Royal Brisbane and Women's Hospital, Gold Coast University Hospital and Robina Hospital were reviewed to identify patients diagnosed with <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ORN<\/jats:styled-content> between January 2003 and May 2017. Data on patient demographics, year of admission and primary disease were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and thirty\u2010eight patients were diagnosed with <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content>, of which 74.4% were <jats:styled-content style=\"fixed-case\">ORN<\/jats:styled-content> and 25.6% were <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content>. Tongue (24.6%), floor of mouth (17.3%) and tonsillar (15.1%) squamous cell carcinomas were the most common primary diseases associated with <jats:styled-content style=\"fixed-case\">ORN<\/jats:styled-content>, with a strong male predominance (80%). Of patients diagnosed with <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content>, 52.5% were taking low\u2010dose antiresorptives for osteoporosis (44.2%), rheumatoid arthritis (4.6%) or Paget's disease (3.3%), while 47.5% were oncology patients receiving high\u2010dose antiresorptives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The number of patients diagnosed with <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ORN<\/jats:styled-content> has trended upwards since 2003. <jats:styled-content style=\"fixed-case\">ORN<\/jats:styled-content> affected three times more patients than <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content>, and patients on low\u2010dose antiresorptives accounted for over half of the <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> 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