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Salivary gland volumes and their correlation with radiation dose were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean radiation dose to oral cavity, parotid and submandibular glands (SMG) was 44.5, 65.0 and 38.6 Gy respectively. Parotid and SMG volumes decreased 33% at 3 months post\u2010radiotherapy; volumes at 2 years post\u2010radiotherapy were 84% and 51% of pre\u2010radiotherapy levels, respectively. Correlations were observed between parotid gland volume per cent reduction and its radiation dose and between resting salivary flow rate reduction and post\u2010radiotherapy\/pre\u2010radiotherapy SMG volume ratio. Salivary flow rates and resting saliva <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> remained significantly low at 2 years post\u2010radiotherapy (both flow rates, <jats:italic>P<\/jats:italic> = 0.001; resting saliva <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>,<jats:italic> P<\/jats:italic> = 0.005). Similarly, xerostomia scores remained significantly higher compared with pre\u2010radiotherapy levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Submandibular gland volumetric shrinkage persisted 2 years after radiotherapy. Xerostomia scores remained significantly higher, and salivary flow rates and resting saliva <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> remained significantly lower, suggesting that study participants were still at risk for hyposalivation\u2010related oral diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12608","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T10:42:26Z","timestamp":1521801746000},"page":"217-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Xerostomia, salivary characteristics and gland volumes following intensity\u2010modulated radiotherapy for nasopharyngeal carcinoma: a two\u2010year follow up"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-1786","authenticated-orcid":false,"given":"CPC","family":"Sim","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry National Dental Centre Singapore Singapore Singapore"},{"name":"Duke\u2010NUS Medical School Singapore Singapore"},{"name":"Oral Health Cooperative Research Centre Melbourne Dental School University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YL","family":"Soong","sequence":"additional","affiliation":[{"name":"Duke\u2010NUS Medical School Singapore Singapore"},{"name":"Division of Radiation Oncology National Cancer Centre Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EPP","family":"Pang","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology National Cancer Centre Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Epidemiological Sciences National Cancer Centre Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GD","family":"Walker","sequence":"additional","affiliation":[{"name":"Oral Health Cooperative Research Centre Melbourne Dental School University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DJ","family":"Manton","sequence":"additional","affiliation":[{"name":"Oral Health Cooperative Research Centre Melbourne Dental School University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EC","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Oral Health Cooperative Research Centre Melbourne Dental School University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JTS","family":"Wee","sequence":"additional","affiliation":[{"name":"Duke\u2010NUS Medical School Singapore Singapore"},{"name":"Division of Radiation Oncology National Cancer Centre Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00055-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66698-6"},{"key":"e_1_2_8_5_1","unstructured":"Singapore Cancer Registry Report.Singapore Cancer Registry Annual Registry Report: trends in cancer incidence in Singapore 2010\u20132014. 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