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Studies published in English and other languages from 1960 till February 2017 were searched in electronic databases. Inclusion criteria were: randomized controlled clinical trials and longitudinal studies that involved non\u2010invasive preventive treatment. We excluded: <jats:italic>in vivo<\/jats:italic> studies and incidence studies. 805 potential articles were located, of 38 full text reviews, 10 were included. Two types of studies were found; those reporting the mean percentage of lesion progression as progression estimate and those reporting the survival rate of lesions presented as the mean or median survival time in months as survival estimate. Weak evidence suggests it would appear that the most effective secondary preventive intervention was one involving a combination of silver fluoride and stannous fluoride, but this has not been substantiated. To inform treatment protocols better, it is recommended (i) that new well\u2010designed <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s are conducted to test the effectiveness of different forms of fluoride to arrest lesion progression in deciduous teeth and (ii) to continue ongoing research into the caries preventive effects of approximal surface sealants.<\/jats:p>","DOI":"10.1111\/adj.12646","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T14:08:54Z","timestamp":1533305334000},"page":"422-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deciduous dentition approximal caries lesion progression and regression following preventive treatment: literature review"],"prefix":"10.1111","volume":"63","author":[{"given":"A","family":"Pakdaman","sequence":"first","affiliation":[{"name":"Department of Community Oral Health School of Dentistry Tehran University of 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