{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:58:52Z","timestamp":1785524332074,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008451","name":"College of Medicine and Dentistry, James Cook University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004799","name":"Australian Dental Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The usefulness of administrating adjunctive systemic antibiotics to expedite healing of periodontal tissues is a topic of interest given the lack of clear guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare clinical outcomes in patients given adjunctive azithromycin (<jats:styled-content style=\"fixed-case\">AZ<\/jats:styled-content>), adjunctive amoxicillin plus metronidazole (<jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>), or scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) alone in the treatment of moderate\u2010to\u2010severe chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight patients were randomly assigned into: <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> alone; 500\u00a0mg <jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content> plus 400\u00a0mg <jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content> three times per day for 7\u00a0days; or 500\u00a0mg <jats:styled-content style=\"fixed-case\">AZ<\/jats:styled-content> for 3\u00a0days. Antibiotics were administered after the first <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> session and clinical parameters for full\u2010mouth and baseline probing pocket depth (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) categories were reviewed 2\u2010months post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four of 38 patients completed the study. All groups experienced significant improvements in full\u2010mouth clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>), probing pocket depth (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) and bleeding on probing. <jats:styled-content style=\"fixed-case\">AZ<\/jats:styled-content> exhibited greater reductions in <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> alone for baseline severe sites, whilst <jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content> showed significant improvements in <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> alone for baseline moderate and severe sites. Of the two antibiotic therapies, <jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content> showed greater reductions in <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">AZ<\/jats:styled-content> in baseline moderate sites only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For patients with moderate\u2010to\u2010severe periodontitis, adjunctive systemic antibiotics might result in greater clinical benefits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12674","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T07:26:07Z","timestamp":1547105167000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Comparing the periodontal tissue response to non\u2010surgical scaling and root planing 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