{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:29:23Z","timestamp":1775604563352,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T00:00:00Z","timestamp":1571356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Breast cancer is the most common cancer affecting women in Australia, and second overall for all Australians. Molecular targets have been developed in the management of breast cancer to allow directed therapy. Complications such as nausea and vomiting can be common as well as less common such as osteonecrosis of the jaw (ONJ). While previously thought to be attributable only to bisphosphonate medications, there has been an increase in recognition of other medications that may also cause this complication. This case report demonstrates a first instance of osteonecrosis of the jaw attributable to pertuzumab and trastuzumab, indicated in the management of HER2\u2010positive metastatic breast cancer, in a patient na\u00efve to ONJ\u2010associated anti\u2010resorptive medications. Following sequestrectomy, the patient had an uncomplicated postoperative healing 5\u00a0months following intervention. With increasing medications being used for a number of malignant conditions such as this, an awareness of less common complications such as ONJ among dental and medical specialties is highlighted in this case report.<\/jats:p>","DOI":"10.1111\/adj.12723","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T14:10:25Z","timestamp":1570111825000},"page":"305-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Osteonecrosis of the jaw in an anti\u2010resorptive na\u00efve patient taking trastuzumab and pertuzumab: case report"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9171-9878","authenticated-orcid":false,"given":"T","family":"Manzie","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Surgery Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Vujcich","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Chan","sequence":"additional","affiliation":[{"name":"Breast Cancer Research Centre Western Australia &amp; Curtin University Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,18]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"ABS.Breast cancer statistics. 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Accessed 6 November 2018."},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-015-0648-2","article-title":"The benefit of HER2\u2010targeted therapies on overall survival of patients with metastatic HER2\u2010positive breast cancer \u2013 a systematic review","volume":"17","author":"Mendes D","year":"2015","journal-title":"Breast Cancer Res"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn653"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8071579"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2016.05.07"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2017.43.2.120"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12254"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000671"},{"key":"e_1_2_5_12_1","first-page":"273","article-title":"Pertuzumab: new hope for patients with HER2\u2010positive breast","volume":"24","author":"Capelan M","year":"2013","journal-title":"Cancer"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200204000-00013"}],"container-title":["Australian Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadj.12723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adj.12723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adj.12723","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adj.12723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T08:07:36Z","timestamp":1693728456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adj.12723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,18]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/adj.12723"],"URL":"https:\/\/doi.org\/10.1111\/adj.12723","archive":["Portico"],"relation":{},"ISSN":["0045-0421","1834-7819"],"issn-type":[{"value":"0045-0421","type":"print"},{"value":"1834-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,18]]},"assertion":[{"value":"2019-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}