{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:47:14Z","timestamp":1781297234475,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of study was to evaluate galectin\u20103 levels in gingival crevicular fluid (GCF) from periodontally healthy (H) patients and those with periodontitis (P), gingivitis (G) and the effect of initial periodontal treatment on GCF galectin\u20103 level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 75 participants, 25 patients with periodontitis, 25 with gingivitis and 25 periodontally healthy subjects were included into the study. Patients with periodontal disease received initial periodontal treatment. GCF galectin\u20103 level was assessed at baseline and at the 6th\u20108th weeks after completion of periodontal treatment. GCF galectin\u20103 level was evaluated by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GCF galectin\u20103 level was the lowest in the H group (102.31[63.07]\u00a0\u03bcg\/30\u00a0s), followed by the G group (241.45[145.89]\u00a0\u03bcg\/30\u00a0s) and the highest in the P group (338.27[219.37]\u00a0\u03bcg\/30\u00a0s). These differences were statistically significant between H and the other groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). After initial periodontal treatment, GCF galectin\u20103 level significantly decreased in the G and P groups compared to baseline values (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study suggest that GCF galectin\u20103 level is a potential biomarker for the evaluation of gingival inflammation and initial periodontal treatment is effective in decreasing GCF galectin\u20103 level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12815","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T01:06:37Z","timestamp":1609376797000},"page":"169-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of initial periodontal treatment on gingival crevicular fluid galectin\u20103 levels in participants with periodontal disease"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-4159","authenticated-orcid":false,"given":"M","family":"Karsiyaka Hendek","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Kirikkale University Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-8589","authenticated-orcid":false,"given":"E","family":"Olgun","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Kirikkale University Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-6810","authenticated-orcid":false,"given":"U","family":"Kisa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Kirikkale University Kirikkale 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