{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:01:23Z","timestamp":1787590883010,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The cysteine challenge test is often used to check the H<jats:sub>2<\/jats:sub>S production capacity of the mouth. Patients with oral halitosis group (n\u2009=\u2009305) or non\u2010oral halitosis group (n\u2009=\u2009191) and healthy individuals (control group, n\u2009=\u2009102) were compared with each other to identify any possible relationship between initial and cysteine\u2010induced oral H<jats:sub>2<\/jats:sub>S concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Method<\/jats:title><jats:p>The medical records of 598 participants were reviewed retrospectively. Oral H<jats:sub>2<\/jats:sub>S concentrations before (pre\u2010CR) and after cysteine rinse (post\u2010CR) with 5\u2009mL of 20\u2009mmol <jats:italic>L\u2010<\/jats:italic>cysteine solution for 30\u2009s were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pre\u2010CR H<jats:sub>2<\/jats:sub>S concentrations were &gt;0.8\u2009ppm in 75.1% of oral group patients but less than &lt;0.8\u2009ppm in 87.3% of the non\u2010oral group and 86.9% of controls. After cysteine rinse, oral H<jats:sub>2<\/jats:sub>S concentrations exceeded 12\u2009ppm in 72% of the oral halitosis patients but were lower in 88% of non\u2010oral group and 99% of controls. Whilst post\u2010CR\/pre\u2010CR ratio was &gt;12 in 74.5% of the oral group, it was &lt;12 in 81.7% of the non\u2010oral group and 83.4% of controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cysteine challenge test can be used as a diagnostic tool to identify an individual's tendency to produce oral malodor, not only to quantify momentary halitosis level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12884","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T05:42:50Z","timestamp":1635918170000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cysteine challenge test as a novel diagnostic tool to distinguish oral halitosis"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-8999","authenticated-orcid":false,"given":"Murat","family":"Aydin","sequence":"first","affiliation":[{"name":"Private 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