{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:38:01Z","timestamp":1789673881030,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study compared natural root caries lesions with artificial root caries lesions prepared with one of the two demineralising solutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve natural root caries lesions on upper incisors and 24 artificial root lesions were prepared on sound root surfaces using 50\u2009mM acetic acid, 1.5\u2009mM CaCl<jats:sub>2<\/jats:sub>, 0.9\u2009mM KH<jats:sub>2<\/jats:sub>PO<jats:sub>4<\/jats:sub> at pH 5.0 or 80\u2009mL\/L Noverite K\u2010702 polyacrylate solution, 500\u2009mg\/L hydroxyapatite, 0.1\u2009mol\/L lactic acid at pH 4.8 (n\u2009=\u200912\/group) for 96 hours. Lesions were scanned using micro\u2010CT. Inciso\u2010gingival oriented images were analysed and mineral density calculated at 7.5\u2009\u03bcm increments from the surface to 225\u2010\u03bcm deep. Sectioned lesions were analysed by Knoop microhardness up to 250\u2009\u03bcm from the lesion surface. Data were analysed by the Dunn's test with Bonferroni correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Natural and artificial lesion mean mineral densities were not statistically different (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Mineral density from the surface to 75\u2009\u03bcm was greater in natural lesions and from 150 to 225\u2009\u03bcm was greater in artificial lesions (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Microhardness values were statistically higher in artificial lesions (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); no difference was found among artificial lesions produced by the two solutions (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Mineral density and microhardness of natural and artificial root caries are different from each other. A greater mineralized surface layer existed on natural lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12957","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T10:18:49Z","timestamp":1681813129000},"page":"120-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of natural and artificial root caries lesions using microcomputed tomography and microhardness test"],"prefix":"10.1111","volume":"68","author":[{"given":"Y","family":"Tsuda","sequence":"first","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Australia"},{"name":"Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1439-4509","authenticated-orcid":false,"given":"JEA","family":"Palamara","sequence":"additional","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-0459","authenticated-orcid":false,"given":"R","family":"Hardiman","sequence":"additional","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-0515","authenticated-orcid":false,"given":"J","family":"Tagami","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9735-1904","authenticated-orcid":false,"given":"MF","family":"Burrow","sequence":"additional","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Australia"},{"name":"Division of Restorative Dental Sciences, Faculty of Dentistry The University of Hong Kong  Pokfulam Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12676"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.10.020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.10.019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00111-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.09.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201302357"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000371897"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2012-243"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2013.12.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.10.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1985.tb00538.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12249"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000261026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2000.tb00238.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000260692"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb00753.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.11.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121611"}],"container-title":["Australian Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adj.12957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T00:51:28Z","timestamp":1692492688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adj.12957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/adj.12957"],"URL":"https:\/\/doi.org\/10.1111\/adj.12957","archive":["Portico"],"relation":{},"ISSN":["0045-0421","1834-7819"],"issn-type":[{"value":"0045-0421","type":"print"},{"value":"1834-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]},"assertion":[{"value":"2023-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}