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Following a better understanding of the histopathology of deep carious lesions, the histology of the cariously exposed pulp and the healing potential of the inflamed pulp, vital pulp therapy (VPT) is increasingly adopted around the world for the management of permanent teeth with clinical signs and symptoms indicative of irreversible pulpitis. Furthermore, VPT became a recognized treatment modality by the European Society of Endodontology (ESE) and the American Association of Endodontists (AAE) by virtue of its high success rates reported in outcome studies using contemporary hydraulic calcium silicate\u2010based cements. However, proper case selection, strict asepsis, capping materials and good coronal seal are mandatory for success. The aim of this paper is to review the biological basis for VPT in symptomatic teeth with carious pulp exposure and to report on the outcome of pulpotomy in teeth with clinical diagnosis of irreversible pulpitis.<\/jats:p>","DOI":"10.1111\/adj.12997","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T18:09:42Z","timestamp":1700590182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Vital pulp therapy for permanent teeth with diagnosis of irreversible pulpitis: biological basis and outcome"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-3871","authenticated-orcid":false,"given":"B","family":"Kahler","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health School of Dentistry, The University of Sydney  Surrey Hills New South Wales 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