{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:25:35Z","timestamp":1791588335233,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medication\u2010related osteonecrosis of the jaw (MRONJ) is a serious, debilitating condition of the jaw bones. Dental extraction is the most significant independent risk factor for MRONJ. This interim study aimed to evaluate the demographics, medical data and outcomes of patients at risk for MRONJ who underwent dental extractions in a dedicated MRONJ clinic following a risk reduction protocol at a large public dental clinic in New South Wales Health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study analysed demographic and clinical data of patients at risk for MRONJ who underwent dental extractions between March 2020 and April 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 329 at\u2010risk patients who underwent 836 dental extractions were included. Most patients were women (75.1%) with a median age of 74\u2009years (IQR 67\u201380). The primary indication for medications was osteoporosis (85.4%), with Denosumab being the most frequently prescribed (66.9%). Eighteen patients (5.5%) developed MRONJ at 8\u2009weeks of follow\u2010up. Patients categorized as high\u2010risk had a higher incidence of MRONJ (72.2%) compared to the low\u2010risk group (22.2%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study is the first retrospective audit carried out after implementing preventive protocols in this dedicated MRONJ clinic. The higher incidence of MRONJ in patients classified as \u2018high risk\u2019 underscores the importance of considering individual risk factors in their treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/adj.13050","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T06:47:22Z","timestamp":1734072442000},"page":"70-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevention of medication\u2010related osteonecrosis of the jaw: institutional insights from a retrospective study"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6091-5811","authenticated-orcid":false,"given":"YS","family":"Chang","sequence":"first","affiliation":[{"name":"The School of Dentistry, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Nepean Centre for Oral Health Nepean Hospital, NBMLHD Kingswood  Penrith New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5479-9650","authenticated-orcid":false,"given":"S","family":"Nanayakkara","sequence":"additional","affiliation":[{"name":"The School of Dentistry, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Yaacoub","sequence":"additional","affiliation":[{"name":"The School of Dentistry, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Nepean Centre for Oral Health Nepean Hospital, NBMLHD Kingswood  Penrith New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SC","family":"Cox","sequence":"additional","affiliation":[{"name":"The School of Dentistry, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Nepean Centre for Oral Health Nepean Hospital, NBMLHD Kingswood  Penrith New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.99.132"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14681"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh141"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809493"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.7101"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2011.03.015"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2022.02.008"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2016.1177021"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4501-x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.11.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2405"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12708"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.10.061"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-4003-2"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.08.015"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02828-w"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2018.1528711"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06018-x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.02.010"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2017.1348001"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-018-0362-5"},{"key":"e_1_2_12_25_1","volume-title":"Therapeutic guidelines: oral and dental. 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