{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:21:09Z","timestamp":1788153669523,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Non\u2010odontogenic orofacial pain (OFP) is a common presentation in oral medicine and frequently co\u2010occurs with sleep disturbances. Health\u2010related and oral health\u2010related quality of life (HRQoL\/OHRQoL) are clinically meaningful outcomes; however, the relationship between sleep disturbances and quality of life (QoL) across non\u2010odontogenic OFP conditions has not been comprehensively synthesised. This systematic review investigated the relationship between sleep disturbances and non\u2010odontogenic OFP in adults and assessed their impact on HRQoL and OHRQoL. The review was conducted in accordance with PRISMA 2020 guidelines. PubMed, MEDLINE, EMBASE and CINAHL Ultimate were searched from inception to November 2025. Eligible studies included adults with non\u2010odontogenic OFP, assessed sleep disturbance using validated or self\u2010reported measures, and reported QoL outcomes. Methodological quality was assessed using Joanna Briggs Institute critical appraisal tools. Due to heterogeneity, results were synthesised narratively. Nine studies were included, encompassing temporomandibular disorders, burning mouth syndrome, painful post\u2010traumatic trigeminal neuropathy, and other chronic non\u2010odontogenic OFP conditions. Across studies, poorer sleep was consistently associated with reduced QoL, including lower vitality, impaired daily functioning, greater emotional distress and increased pain\u2010related interference. Sleep disturbances were consistently associated with reduced HRQoL\/OHRQoL in adults with non\u2010odontogenic OFP. Sleep disturbances are frequently reported in adults with non\u2010odontogenic orofacial pain and are associated with meaningful reductions in both health\u2010related and oral health\u2010related quality of life. This review highlights the importance of considering sleep as a clinically relevant component of the assessment of chronic orofacial pain conditions, including temporomandibular disorders, burning mouth syndrome and painful post\u2010traumatic trigeminal neuropathy. Incorporating routine enquiry regarding sleep may facilitate identification of patients with greater functional, psychological, and pain\u2010related burden, supporting a more comprehensive biopsychosocial approach to patient management. Recognition of sleep\u2010related impairment may also assist clinical decision\u2010making, improve communication with patients, and support timely interdisciplinary referral where indicated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:styled-content style=\"fixed-case\">Trial<\/jats:styled-content>\n                      Registration\n                    <\/jats:title>\n                    <jats:p>PROSPERO Registration: CRD420251071445<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/adj.70066","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:53:16Z","timestamp":1788151996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship Between Sleep Disturbances and Non\u2010Odontogenic Orofacial Pain and Its Impact on Quality of Life: A Systematic Review With Narrative Synthesis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-0907","authenticated-orcid":false,"given":"Jainy","family":"Shah","sequence":"first","affiliation":[{"name":"School of Dentistry, Adelaide University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-5298","authenticated-orcid":false,"given":"Sneha","family":"Sethi","sequence":"additional","affiliation":[{"name":"Australian Research Centre for Population Oral Health, School of Dentistry, Adelaide University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-6104","authenticated-orcid":false,"given":"Brianna","family":"Poirier","sequence":"additional","affiliation":[{"name":"Australian Research Centre for Population Oral Health, School of Dentistry, Adelaide University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8287-1226","authenticated-orcid":false,"given":"Giampiero","family":"Rossi\u2010Fedele","sequence":"additional","affiliation":[{"name":"School of Dentistry, Adelaide University  Adelaide South Australia Australia"},{"name":"Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences, Saveetha University  Chennai India"},{"name":"Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"issue":"2","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/0333102419893823","article-title":"International Classification of Orofacial Pain, 1st edition (ICOP)","volume":"40","year":"2020","journal-title":"Cephalalgia"},{"issue":"3","key":"e_1_2_13_3_1","first-page":"1","article-title":"Prevalence of Orofacial and Head Pain: An Umbrella Review of Systematic Reviews","volume":"38","author":"Porporatti A. L.","year":"2024","journal-title":"Journal of Oral & Facial Pain and Headache"},{"issue":"7","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1468-2982.2008.01586.x","article-title":"The International Classification of Headache Disorders: accurate diagnosis of orofacial pain?","volume":"28","author":"Benoliel R.","year":"2008","journal-title":"Cephalalgia"},{"issue":"2","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.joen.2009.11.007","article-title":"Frequency of persistent tooth pain after root canal therapy: a systematic review and meta\u2010analysis","volume":"36","author":"Nixdorf D. R.","year":"2010","journal-title":"Journal of Endodontics"},{"issue":"3","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.joen.2020.12.002","article-title":"New International Classification of Orofacial Pain: What Is in It For Endodontists?","volume":"47","author":"Pigg M.","year":"2021","journal-title":"Journal of Endodontics"},{"issue":"1","key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.oooo.2016.08.016","article-title":"The Impact of Chronic Orofacial Pain on Daily Life: The Vulnerable Patient and Disruptive Pain","volume":"123","author":"Haviv Y.","year":"2017","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology"},{"issue":"2","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1515\/sjpain-2019-0131","article-title":"The Impact of Chronic Orofacial Pain on Health\u2010Related Quality of Life","volume":"20","author":"Forssell H.","year":"2020","journal-title":"Scandinavian Journal of Pain"},{"issue":"6","key":"e_1_2_13_9_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-0528.2007.00418.x","article-title":"What Do Measures of Oral Health\u2010Related Quality of Life Measure?","volume":"35","author":"Locker D.","year":"2007","journal-title":"Community Dentistry and Oral Epidemiology"},{"issue":"4","key":"e_1_2_13_10_1","first-page":"316","article-title":"Pain and the Quality of Life in Patients Referred to a Craniofacial Pain Unit","volume":"10","author":"Murray H.","year":"1996","journal-title":"Journal of Orofacial Pain"},{"issue":"10","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1177\/0022034516648264","article-title":"The Neurobiology of Orofacial Pain and Sleep and Their Interactions","volume":"95","author":"Lavigne G. J.","year":"2016","journal-title":"Journal of Dental Research"},{"key":"e_1_2_13_12_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2024.101939","article-title":"Effect of sleep on oral health: A scoping review","volume":"76","author":"Shah J.","year":"2024","journal-title":"Sleep Medicine Reviews"},{"key":"e_1_2_13_13_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2024.1485822","article-title":"Bidirectional relationship between pain and sleep disturbance in middle\u2010aged and older adults: evidence from the China health and retirement longitudinal study","volume":"15","author":"Yi D.","year":"2024","journal-title":"Frontiers in Psychiatry"},{"key":"e_1_2_13_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101467","article-title":"Prevalence of Sleep Disturbances in Patients With Chronic Non\u2010Cancer Pain: A Systematic Review and Meta\u2010Analysis","volume":"57","author":"Sun Y.","year":"2021","journal-title":"Sleep Medicine Reviews"},{"issue":"2","key":"e_1_2_13_15_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: A New Instrument for Psychiatric Practice and Research","volume":"28","author":"Buysse D. 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D.","year":"2007","journal-title":"Pain"},{"issue":"4","key":"e_1_2_13_33_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/odi.12807","article-title":"The association between burning mouth syndrome and sleep disturbance: A case\u2010control multicentre study","volume":"24","author":"Adamo D.","year":"2018","journal-title":"Oral Diseases"},{"issue":"8","key":"e_1_2_13_34_1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/joor.12994","article-title":"The impact of oro\u2010facial pain conditions on oral health\u2010related quality of life: A systematic review","volume":"47","author":"Oghli I.","year":"2020","journal-title":"Journal of Oral Rehabilitation"},{"key":"e_1_2_13_35_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s10194-015-0504-x","article-title":"Sleep Disturbances and Quality of Life in Sub\u2010Saharan African Migraineurs","volume":"16","author":"Morgan I.","year":"2015","journal-title":"Journal of Headache and Pain"},{"issue":"6","key":"e_1_2_13_36_1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s10072-016-2505-1","article-title":"Fatigue, sleep\u2010wake pattern, depressive and anxiety symptoms and body\u2010mass index: analysis in a sample of episodic and chronic migraine patients","volume":"37","author":"Lucchesi C.","year":"2016","journal-title":"Neurological Sciences"},{"key":"e_1_2_13_37_1","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.955298","article-title":"Association between sleep quality, migraine and migraine burden","volume":"13","author":"Duan S.","year":"2022","journal-title":"Frontiers in Neurology"}],"container-title":["Australian Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adj.70066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adj.70066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adj.70066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:53:33Z","timestamp":1788152013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adj.70066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,30]]},"references-count":36,"alternative-id":["10.1111\/adj.70066"],"URL":"https:\/\/doi.org\/10.1111\/adj.70066","archive":["Portico"],"relation":{},"ISSN":["0045-0421","1834-7819"],"issn-type":[{"value":"0045-0421","type":"print"},{"value":"1834-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,30]]},"assertion":[{"value":"2026-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"adj.70066"}}