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Group 1, received a single dose of Paracetamol alone (G\u20101), Group 2 received combined Ibuprofen\/Paracetamol (G\u20102). Group 3 received combined Mefenamic acid\/Paracetamol (G\u20103), group 4 received combined Diclofenac K\/Paracetamol (G\u20104) and Group 5 received a placebo (G\u20105). There were no statistically significant differences in pain reduction between males and females whilst there were statistically significant differences between them and the placebo group. All combinations of Paracetamol performed better in pain reduction than the placebo among females, while there were no statistically significant differences among males. In conclusion, there were no differences in pain reduction between males and females, and arch for the tested analgesics taken immediately following initial endodontic therapy in teeth with irreversible pulpitis.<\/jats:p>","DOI":"10.1111\/aej.12218","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T05:12:39Z","timestamp":1508130759000},"page":"215-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gender and arch effects on the use of non\u2010opioid analgesics for post endodontic pain reduction"],"prefix":"10.1111","volume":"44","author":[{"given":"Wail M.","family":"Elzaki","sequence":"first","affiliation":[{"name":"Faculty of Dentistry King Khalid University Abha Saudi Arabia"},{"name":"Department of Oral Rehabilitation Faculty of Dentistry University of Khartoum Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan 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