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A search was performed in PubMed, Scopus, Web of Science, <jats:styled-content style=\"fixed-case\">LILACS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BBO<\/jats:styled-content>, Cochrane Library, <jats:styled-content style=\"fixed-case\">SIGLE<\/jats:styled-content>, and grey literature. The risk of bias was evaluated through the Cochrane Collaboration's tool. The quality of evidence was assessed using the <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content> approach. Only seven studies remained for the meta\u2010analysis. Administering ibuprofen before anaesthesia increased the success rate of injectable anaesthesia (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> = 1.79; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.32\u20132.42; <jats:italic>P<\/jats:italic> = 0.0002) even in cases of symptomatic irreversible pulpitis (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> = 1.55; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.05\u20132.29; <jats:italic>P<\/jats:italic> = 0.03). The intensity of pain was lower for ibuprofen (standardised difference means (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>) = \u22123.73; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22126.43 to \u22121.04; <jats:italic>P<\/jats:italic> = 0.007). Ibuprofen as premedication is beneficial for the success of inferior alveolar nerve block.<\/jats:p>","DOI":"10.1111\/aej.12306","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T01:25:19Z","timestamp":1538961919000},"page":"246-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of ibuprofen on the efficacy of inferior alveolar nerve block in patients with irreversible pulpitis: A meta\u2010analysis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-0474","authenticated-orcid":false,"given":"Juliana L.","family":"de Geus","sequence":"first","affiliation":[{"name":"Department of Dentistry. 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