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A total of 42 patients with pain due to acute irreversible pulpitis in carious premolar and molar teeth were included in this study. The four irrigation groups were as follows: saline (<jats:italic>n<\/jats:italic>\u00a0=\u00a011), 3% sodium hypochlorite (<jats:italic>n<\/jats:italic>\u00a0=\u00a011), ketorolac tromethamine (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) and dexamethasone (<jats:italic>n<\/jats:italic>\u00a0=\u00a010). Blood samples S1 and S2 were collected upon access opening and after canal preparation, respectively. Quantification of substance P and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 were done using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> test. Post\u2010operative pain was assessed by questioning the patients. The difference between S1 and S2 sample values for the four different irrigant groups was not significant. The sodium hypochlorite group had a higher mean expression of substance P and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 values. Dexamethasone irrigation was more effective in controlling post\u2010operative pain.<\/jats:p>","DOI":"10.1111\/aej.12340","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T02:43:17Z","timestamp":1562208197000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Influence of different irrigants on substance P and <scp>IL<\/scp>\u20108 expression for single visit root canal treatment in acute irreversible pulpitis"],"prefix":"10.1111","volume":"46","author":[{"given":"J.","family":"Evangelin","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics CSI College of Dental Sciences Madurai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-9842","authenticated-orcid":false,"given":"I. Anand","family":"Sherwood","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics CSI College of Dental Sciences Madurai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5727-4211","authenticated-orcid":false,"given":"Paul V.","family":"Abbott","sequence":"additional","affiliation":[{"name":"UWA Dental School The University of Western Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Uthandakalaipandian","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology School of Biological Sciences Madurai Kamaraj University Madurai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Velu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology School of Biological Sciences Madurai Kamaraj University Madurai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01316.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.12.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12059"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2004.00836.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2009.01562.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092050407"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1381521"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12030"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.02.009"},{"key":"e_1_2_8_11_1","first-page":"241","volume-title":"Seltzer and Bender's Dental Pulp","author":"Fouad AF","year":"2012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00451.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.04.026"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/951920"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200407000-00006"},{"key":"e_1_2_8_16_1","first-page":"324","volume-title":"Pharmacology and Therapeutics for Dentistry","author":"Harsh EV","year":"2014"},{"key":"e_1_2_8_17_1","first-page":"1478","volume-title":"Goodman and Gilman's: the pharmacological basis of therapeutics","author":"Goodman\u2010Gilman A","year":"1985"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2007.tb00527.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2004.00923.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2004.00820.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12749"},{"key":"e_1_2_8_22_1","first-page":"14","article-title":"Influence of anti\u2010inflammatory irrigants on substance P expression for single visit root canal treatment of teeth with irreversible pulpitis","volume":"44","author":"Bamini L","year":"2018","journal-title":"Aust Endod J"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81176-3"},{"key":"e_1_2_8_24_1","first-page":"159","volume-title":"Seltzer and Bender's Dental Pulp","author":"Diogenes A","year":"2012"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(89)90310-1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2003.00735.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1992.tb00748.x"},{"key":"e_1_2_8_28_1","unstructured":"TarabishyK.Postoperative pain after the use of a dexamethasone rinse as an irrigant prior to obturation. 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