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Two reviewers independently conducted a systematic literature search in the PubMed (MEDLINE), Dentistry &amp; Oral Sciences Source and the Cochrane Library databases. Seven studies were included, of which three were used to perform meta\u2010analysis for 6\u00a0days post\u2010operative and the rest for qualitative synthesis. Three studies were assessed as low risk of bias, three as some concern, and one as high risk of bias. Occlusal reduction diminishes the post\u2010operative pain (SMD \u22121.10 (95%CI \u22122.06, \u22120.15) <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a096.9%) at 6\u00a0days for teeth diagnosed as irreversible pulpitis, and, overall, likely reduces post\u2010operative pain for patients presenting with irreversible pulpitis and\/or symptomatic apical periodontitis. Future high\u2010quality clinical trials are needed to better understand the role of occlusal reduction.<\/jats:p>","DOI":"10.1111\/aej.12380","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T10:18:55Z","timestamp":1571739535000},"page":"282-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of occlusal reduction on postendodontic pain: A systematic review and meta\u2010analysis of randomised clinical trials"],"prefix":"10.1111","volume":"46","author":[{"given":"David","family":"Nguyen\u2010Nhon","sequence":"first","affiliation":[{"name":"Melbourne Dental School University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7713-0418","authenticated-orcid":false,"given":"Venkateshbabu","family":"Nagendrababu","sequence":"additional","affiliation":[{"name":"Division of Clinical 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