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Histological studies have demonstrated that clinically diagnosed irreversible pulpitis does not involve the entire pulp. A recent International Endodontic Journal Editorial suggested clinical diagnosis of pulp disease should be reassessed because of the poor correlation between clinical symptoms and pulp sensibility testing and the actual histological status of the pulp. This review identified studies in a PubMed search that provide evidence for vital pulp therapy (VPT) of mature permanent teeth with irreversible pulpitis is predictable if correctly diagnosed and properly treated. A narrative review was undertaken to outline the correlation between the clinical symptoms\/signs and pulp sensibility testing and the histological findings of the pulp. Treatment procedures for permanent teeth are outlined.<\/jats:p>","DOI":"10.1111\/aej.12392","type":"journal-article","created":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T01:45:05Z","timestamp":1576979105000},"page":"154-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":140,"title":["Vital pulp therapy of mature permanent teeth with irreversible pulpitis from the perspective of pulp biology"],"prefix":"10.1111","volume":"46","author":[{"given":"Louis M.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Endodontics New York University College of Dentistry New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-6722","authenticated-orcid":false,"given":"Domenico","family":"Ricucci","sequence":"additional","affiliation":[{"name":"Private Practice Cetraro 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