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A number of cases of florid osseous dysplasia (FOD) have been described; however, to our knowledge none have shown radiographic disease progression for a single case involving multiple regions of the jaws over an extended period of time. This report presents the 18\u2010year history and radiographic disease progression of a patient diagnosed with FOD demonstrating progression from the osteolytic phase through the osteoblastic phase and to maturation phase at different intervals. Additionally, it outlines the importance of cone beam computed tomography (CBCT) in diagnostic workup to avoid unnecessary and invasive treatment such as bone biopsy, endodontic treatment or tooth extraction due to misdiagnosis of FOD. Dental practitioners should establish a correct diagnosis themselves by making use of important clinical and radiographic cues such as tooth vitality of affected teeth, or by referral to an appropriate specialist before commencing irreversible dental treatment.<\/jats:p>","DOI":"10.1111\/aej.12530","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T21:10:24Z","timestamp":1622581824000},"page":"684-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Natural history of florid osseous dysplasia of the jaws with important clinical implications"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-6204","authenticated-orcid":false,"given":"Camile S.","family":"Farah","sequence":"first","affiliation":[{"name":"The Oral Medicine Clinic Hollywood Private Hospital Nedlands Western Australia Australia"},{"name":"Qscan Radiology Clinics Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Anne T.","family":"Matias","sequence":"additional","affiliation":[{"name":"Qscan Radiology Clinics Brisbane Queensland Australia"},{"name":"Perth Radiological Clinic Subiaco Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6]]},"reference":[{"volume-title":"World Health Organisation classification of tumours pathology and genetics of head and neck tumours","year":"2005","author":"Barnes L","key":"e_1_2_6_2_1"},{"volume-title":"WHO Classification of Head and Neck Tumours","year":"2017","author":"El\u2010Naggar 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