{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:21:47Z","timestamp":1787937707072,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007086","name":"Sel\u00e7uk \u00dcniversitesi","doi-asserted-by":"publisher","award":["12202014"],"award-info":[{"award-number":["12202014"]}],"id":[{"id":"10.13039\/501100007086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate the biocompatibility of epoxy\u2010resin\u2010based AHPlus, salicylate\u2010based MTA\u2010Fillapex and calcium silicate\u2010based iRootSP root canal sealers. Cytotoxicity was assessed by XTT test. The extracts from sealers of different setting times were serially diluted. Cell viability was calculated as the percentage of the control group (100%). The optimal concentration of each sealer was used at genotoxicity test, and micronuclei formations were detected. Statistical analyses were done by using Kruskal\u2013Wallis and Dunn post hoc test with Bonferroni correction. AHPlus and MTA\u2010Fillapex showed the lowest percentage of cell viability at higher concentrations (1:1, 1:2, 1:4), especially at first 12\u2009h. iRootSP showed higher viability at all concentrations and times than AHPlus and MTA\u2010Fillapex. At genotoxicity assay, AHPlus increased the number of micronuclei. MTA\u2010Fillapex slightly induced micronucleus formation (not significant) and iRootSP was not increased. In conclusion, calcium silicate\u2010based iRootSP had lowest cytotoxic and genotoxic potential and can be considered as a highly biocompatible material.<\/jats:p>","DOI":"10.1111\/aej.12537","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T15:00:25Z","timestamp":1623078025000},"page":"645-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cytotoxicity and genotoxicity of salicylate\u2010 and calcium silicate\u2010based root canal sealers on primer human periodontal ligament fibroblasts"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-4693","authenticated-orcid":false,"given":"Hilal","family":"Erdogan","sequence":"first","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Nevsehir Haci Bektas Veli University Nevsehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8044-1874","authenticated-orcid":false,"given":"Sibel","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Faculty of Dentistry Selcuk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-0790","authenticated-orcid":false,"given":"Funda Kont","family":"Cobankara","sequence":"additional","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Selcuk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102591.2002.00459.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0109\u20105641(96)80020\u20100"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099\u20102399(06)80436\u2010X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.05.050"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12487"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.10.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000140570.95688.ee"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.11.003"},{"key":"e_1_2_9_10_1","first-page":"557","article-title":"Mineral trioxide aggregate (MTA)\u2010like materials: an update review","volume":"35","author":"Mohammadi Z","year":"2014","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2019\u2010288"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.06.030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.11606\/issn.2357\u20108041.clrd.2014.63160"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20109657.2001.170405.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102591.2010.01733.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.03.050"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.08.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102591.2003.00647.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.9790\/0853\u201013824247"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8030068"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12596"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102184.2006.00390.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u2010775720130047"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.11.006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/etp.12075"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.09.012"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.5505\/TurkHijyen.2011.06977"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770\u2010200401000\u201000005"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13086"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12393"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.57527"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102591.2011.01992.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DON.0000133155.04468.41"}],"container-title":["Australian Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aej.12537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aej.12537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aej.12537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:11:49Z","timestamp":1692684709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aej.12537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,7]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/aej.12537"],"URL":"https:\/\/doi.org\/10.1111\/aej.12537","archive":["Portico"],"relation":{},"ISSN":["1329-1947","1747-4477"],"issn-type":[{"value":"1329-1947","type":"print"},{"value":"1747-4477","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,7]]},"assertion":[{"value":"2021-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}