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Gutta\u2010percha solvents inhibited the proliferation rate of fibroblasts in a dose\u2010 and time\u2010dependent manner; however, no inhibition was detected in HOB (evaluated using MTT assay). None of the solvents induced apoptosis\/necrosis in HOB cells at \u22642.5\u2009\u03bcL\u2009mL<jats:sup>\u22121<\/jats:sup> concentration in contrast to L929 (determined using acridine orange\/ethidium bromide dual staining). Each solvent tested reduced the migration rate of both L929 and HOB cell lines in a dose\u2010dependent manner (evaluated using a scratch assay). Gutta\u2010percha solvents can damage fibroblast\u2010rich tissues. 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