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The <jats:italic>in\u00a0vitro<\/jats:italic> experiment used microtubes to test the mixture of 2.5% NaOCl, 2% CHX and 5% ST solutions, varying their order and time of addition. In the <jats:italic>ex\u00a0vivo<\/jats:italic> experiment, 10 bovine teeth were divided into two groups according to the intermediate irrigant used: distilled water (control) and 5% ST (experimental). Colour change occurred in all microtubes after interaction between solutions. While the precipitate was not observed in the experimental group, it was seen in all specimens of the control group. The 5% ST was able to prevent the formation of the brown\u2010coloured precipitate in the <jats:italic>ex\u00a0vivo<\/jats:italic> experiment, whereas it only prevented its <jats:italic>in\u00a0vitro<\/jats:italic> formation when the waiting time for adding CHX was 10, 15 and 20\u2009min.<\/jats:p>","DOI":"10.1111\/aej.12562","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:42:37Z","timestamp":1631101357000},"page":"72-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Does sodium thiosulphate avoid the formation of the brown\u2010coloured precipitate as an intermediate irrigant between NaOCl and chlorhexidine?"],"prefix":"10.1111","volume":"48","author":[{"given":"Amanda Pereira Leite","family":"Alberto","sequence":"first","affiliation":[{"name":"Department of Endodontics Fluminense Federal University  Niter\u00f3i, Rio de Janeiro 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