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Contaminated dentinal blocks were divided into two control and seven experimental groups (<jats:italic>n<\/jats:italic>\u2009=\u200915): CH, DS, NAC, CH\u2009+\u20095% DS, 50% CH\u2009+\u200950% DS, CH\u2009+\u20095% NAC and 50% CH\u2009+\u200950% NAC. After seven days, dentine debris was obtained from two depths of 100 and 200\u2009\u00b5m. The bacterial load was assessed by counting the number of colony\u2010forming units (CFUs). Pure DS exhibited maximum antibacterial activity at both depths. At 200\u2009\u00b5m, it showed statistically significant differences with all the other groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Mixing CH with either 5% or 50% of DS and NAC did not increase the antibacterial efficacy (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Pure DS was most effective in disinfecting dentinal tubules, and mixing CH with DS or NAC is not recommended.<\/jats:p>","DOI":"10.1111\/aej.12575","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T16:05:44Z","timestamp":1633795544000},"page":"386-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Disinfection of dentinal tubules with diclofenac sodium and N\u2010Acetylcysteine compared with calcium hydroxide as intracanal medicaments against <i>Enterococcus faecalis<\/i>"],"prefix":"10.1111","volume":"48","author":[{"given":"Alireza","family":"Adl","sequence":"first","affiliation":[{"name":"Department of Endodontics, Biomaterials Research Center School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Motamedifar","sequence":"additional","affiliation":[{"name":"Department of Microbiology Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parastoo","family":"Malekzadeh","sequence":"additional","affiliation":[{"name":"Department of Endodontics School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Sedigh\u2010Shams","sequence":"additional","affiliation":[{"name":"Department of Endodontics School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"249","article-title":"The effect of surgical exposure of dental pulps in germ\u2010free and conventional laboratory rats","volume":"28","author":"Kakehashi S","year":"1965","journal-title":"Oral Surg Oral Med Oral 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