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While advances in DNA molecular analysis techniques (PCR) have contributed to the current understanding of the potential role of the varicella zoster virus in the initiation and progression of endodontic disease, a review indicates a need for ongoing research. Case reports are presented of two female patients with a history of herpes zoster who developed pulp necrosis, with one patient progressing to apical periodontitis. Both patients received non\u2010surgical endodontic therapy, followed by intra\u2010coronal bleaching in one of the patients due to tooth discolouration which developed during the prodromal and acute phases of the herpes zoster infection. Clinical and radiographic examinations at 23 and 22\u2009years, respectively, showed the affected teeth to be retained in an asymptomatic and aesthetically satisfactory state with no radiographic evidence of apical pathosis.<\/jats:p>","DOI":"10.1111\/aej.12596","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T04:37:28Z","timestamp":1639197448000},"page":"522-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Herpes Zoster and association with pulp necrosis and development of apical periodontitis \u2013 a review and presentation of two case reports"],"prefix":"10.1111","volume":"48","author":[{"given":"Geoffrey S.","family":"Heithersay","sequence":"first","affiliation":[{"name":"Discipline of Endodontology and Dental Traumatology Adelaide Dental School Faculty of Health Sciences The University of Adelaide  Adelaide South Australia Australia"},{"name":"Discipline of 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