{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:31:13Z","timestamp":1777048273977,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of the study was to investigate the therapeutic effects of \u03b1\u2010lipoic acid (ALA) on an induced\u2010acute pulpitis model in rats. Twenty\u2010four Wistar albino rats were randomly divided into three groups: control, induced\u2010acute pulpitis (PULP) and PULP\u00a0+\u00a0ALA groups. In the PULP and PULP\u00a0+\u00a0ALA groups, the crowns of the maxillary left incisors were removed horizontally. All exposed pulp tissues were treated with 5\u00a0\u00b5L LPS solution. In the PULP\u00a0+\u00a0ALA group, the rats were treated intraperitoneally with a single dose of ALA (100\u00a0mg\/kg). The rats were sacrificed 24\u00a0h after pulp injury, and the trunk blood and pulp samples were collected and then determined using ELISA assay kits. TNF\u2010\u03b1, IL\u20101\u03b2, MMP\u20101 and MMP\u20102\u00a0levels in the serum and pulp tissues were considerably higher in the PULP group than the control group (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01\u20130.001). In the PULP\u00a0+\u00a0ALA group, TNF\u2010\u03b1, IL\u20101\u03b2, MMP\u20101 and MMP\u20102\u00a0levels in the serum and pulp tissues decreased significantly compared to the PULP group (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05\u20130.001). ALA decreases pro\u2010inflammatory mediators and proteolytic enzymes, which might relieve acute inflammation.<\/jats:p>","DOI":"10.1111\/aej.12618","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T16:52:09Z","timestamp":1647363129000},"page":"87-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Does \u03b1\u2010lipoic acid therapeutically effective against experimentally induced\u2010acute pulpitis in rats?"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-5312","authenticated-orcid":false,"given":"Fatma","family":"Kermeo\u011flu","sequence":"first","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Near East University  Nicosia North Cyprus Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Say\u0131ner","sequence":"additional","affiliation":[{"name":"Department of 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