{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:34:48Z","timestamp":1747182888573,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP N\u00b0 262"],"award-info":[{"award-number":["PIP N\u00b0 262"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020190200174BA"],"award-info":[{"award-number":["20020190200174BA"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim was to characterise the endocannabinoid system (ECS) in the dental pulp of teeth at different stages of eruption. Pulp of: erupted premolars (EPM), third molars in pre\u2010eruptive (PThM), intraosseous (IThM) and eruptive stages (EThM) (<jats:italic>n<\/jats:italic>\u00a0=\u200912 each group) were used. Messenger RNA expression of components of the ECS as cannabinoid receptors (CBr1 and CBr2), and anandamide synthetizing (NAPE\u2013PLD) and degradation (FAAH) enzymes were measured by RT\u2013PCR. Data were analysed using Student's <jats:italic>t<\/jats:italic>\u2010test for comparisons between two groups and one\u2010way analysis of variance and Tukey's post\u2010test for multiple comparisons (statistical significance: <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). mRNA expression of CBr2, NAPE\u2013PLD and FAAH was similar in the studied stages, was lower in IThM than in PThM and EThM, and the lowest in EThM (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01); of note, CBr2 mRNA expression was not detected in EThM. CBr1 mRNA did not differ significantly between IThM and PThM but was lower in EThM (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01). The absence of CBr2 and presence of CBr1 in EThM suggest the involvement of the ECS via CBr1 as a mediator of tooth and bone tissue homeostasis during tooth eruption.<\/jats:p>","DOI":"10.1111\/aej.12695","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T12:53:45Z","timestamp":1665665625000},"page":"79-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of the endocannabinoid system in tooth eruption: An ex vivo study"],"prefix":"10.1111","volume":"49","author":[{"given":"Ana Clara","family":"Casadoumecq","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Odontolog\u00eda, C\u00e1tedra de Fisiolog\u00eda  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-3585","authenticated-orcid":false,"given":"Jos\u00e9 Javier","family":"Fern\u00e1ndez\u2010Solari","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Odontolog\u00eda, C\u00e1tedra de Fisiolog\u00eda  Buenos Aires Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnicas (CONICET)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Elverdin","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Odontolog\u00eda, C\u00e1tedra de Fisiolog\u00eda  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Alejandro","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Odontolog\u00eda, C\u00e1tedra de Endodoncia  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2314-2661","authenticated-orcid":false,"given":"Claudia\u00a0Ester","family":"Mohn","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Odontolog\u00eda, C\u00e1tedra de Fisiolog\u00eda  Buenos Aires Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnicas (CONICET)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"volume-title":"Cohen V\u00edas de la pulpa","year":"2011","author":"Cohen S","key":"e_1_2_9_2_1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2006.03.043"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"33","article-title":"The physiopathology of cyclooxygenase\u20101 and cyclooxygenase\u20102","volume":"27","author":"Meijide G","year":"2020","journal-title":"Rev Esp 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