{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:03:06Z","timestamp":1774972986633,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the efficacy of the supplementary use of a rotary agitation method [XP\u2010endo Finisher (XPF)] and sonically\u2010activated irrigation [EndoActivator (EA)], using droplet digital PCR (ddPCR) on reducing the bacterial load in previously root canal treated teeth with apical periodontitis. Twenty patients with post\u2010treatment apical periodontitis were allocated into two groups according to the irrigation activation method used: XPF and EA group. Total bacterial loads, as well as the amount of <jats:italic>Enterococcus faecalis<\/jats:italic> (<jats:italic>E<\/jats:italic>.\u2009<jats:italic>faecalis<\/jats:italic>) were determined before (S1) and after (S2) chemomechanical preparation, and after final irrigation activation (S3) by means of ddPCR. The bacterial copy numbers were compared between groups using the Friedman test (Nonparametric Repeated Measures ANOVA). When the groups were examined in terms of gender, age, number of root canals, periapical index score, sterility control total bacteria (SCTB), S1\u2010 and S2\u2010total bacteria copy number, it was found that there was no statistical difference between the XPF group and the EA group (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Subsequent activation (S3) resulted in a significant microbial reduction in both XPF and EA groups, both of which reduced significantly more bacteria than chemomechanical instrumentation (S2) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). On the contrary, S3\u2010total bacteria copy number of the EA group was lower than the XPF group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0147). There was no statistical difference between the XPF group and the EA group in terms of <jats:italic>E.\u2009faecalis<\/jats:italic> copy number (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Although both the XPF and the EA optimised the antibacterial efficiency of chemomechanical preparation in previously root canal\u2010treated teeth with apical periodontitis, a lower total bacterial copy number was achieved with the EA application than the XPF application.<\/jats:p>","DOI":"10.1111\/aej.12756","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T10:18:53Z","timestamp":1680862733000},"page":"399-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Is <scp>XP<\/scp>\u2010endo Finisher a better treatment option for its efficacy against intracanal bacteria for post\u2010treatment apical periodontitis cases than <scp>E<\/scp>ndo<scp>A<\/scp>ctivator?"],"prefix":"10.1111","volume":"49","author":[{"given":"Yelda Erdem","family":"Hepsenoglu","sequence":"first","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0354-5108","authenticated-orcid":false,"given":"Seyda","family":"Ersahan","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.11.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.10.035"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.07.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.03.010"},{"key":"e_1_2_8_6_1","first-page":"345","article-title":"Removal of oral biofilm by sonic phenomena","volume":"18","author":"Pitt WG","year":"2005","journal-title":"Am J Dent"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.07.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.04.024"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12202"},{"key":"e_1_2_8_10_1","unstructured":"FKG Dentaire.The XP\u2010endo Finisher file brochure.2016http:\/\/www.fkg.ch\/products\/endodontics\/final\u2010preparation\/xp\u2010endofinisher"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.04.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02970-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.03.009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.09.021"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.11.015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2729-y"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1997.tb00714.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1864-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000157989.44949.26"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00603.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2007.00315.x"},{"issue":"84","key":"e_1_2_8_22_1","first-page":"1003","article-title":"Evaluation of a droplet digital polymerase chain reaction format for DNA copy number quantification","volume":"84","author":"Pinheiro LB","year":"2012","journal-title":"Int Endod J"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638715608358"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.t01-1-00111.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00504.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.02.017"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.06.006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200006000-00006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-0707.139833"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.00156.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12783"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.05.009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01767.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.11.022"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.06.009"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.12.027"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1989.tb00910.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2012.02120.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.03.035"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2019.vol33.0021"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030854"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.11.011"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-5984.149080"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12273"}],"container-title":["Australian Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aej.12756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T08:48:50Z","timestamp":1694854130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aej.12756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,7]]},"references-count":43,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/aej.12756"],"URL":"https:\/\/doi.org\/10.1111\/aej.12756","archive":["Portico"],"relation":{},"ISSN":["1329-1947","1747-4477"],"issn-type":[{"value":"1329-1947","type":"print"},{"value":"1747-4477","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,7]]},"assertion":[{"value":"2022-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}