{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:05:02Z","timestamp":1751432702805,"version":"3.40.5"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate whether there is an association between inducible in single nucleotide polymorphisms in nitric oxide synthase (rs2297518 and rs2779249) and persistent apical periodontitis. A total of 291 Brazilian subjects were included: 125 with signs\/symptoms of persistent apical periodontitis and 166 with root canal\u2010treated teeth exhibiting healthy perirradicular tissues. Endodontically treated patients were followed up after 1\u2009year. The two single nucleotide polymorphisms in nitric oxide synthase were analysed using real\u2010time polymerase chain reaction. Chi\u2010square test and odds ratio with 95% confidence intervals were performed to compare genotype distributions between \u2018healed\u2019 and \u2018persistent apical periodontitis\u2019 groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Logistic regression analysis was used to evaluate SNP\u2013SNP interactions. The allele and genotype distributions for the polymorphisms between the persistent apical periodontitis and healed groups were not statistically significant (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). In the logistic regression analysis, the polymorphisms were not associated with persistent apical periodontitis and SNP\u2013SNP interactions.<\/jats:p>","DOI":"10.1111\/aej.12796","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T10:26:11Z","timestamp":1695119171000},"page":"648-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Single nucleotide polymorphisms in inducible nitric oxide synthase gene are not associated with persistent apical periodontitis"],"prefix":"10.1111","volume":"49","author":[{"given":"Sandra Regina Santos","family":"Meyfarth","sequence":"first","affiliation":[{"name":"Postgraduate Program, School of Dentistry Fluminense Federal University  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8432-0815","authenticated-orcid":false,"given":"L\u00edvia Azeredo Alves","family":"Antunes","sequence":"additional","affiliation":[{"name":"Postgraduate Program, School of Dentistry Fluminense Federal University  Niter\u00f3i Brazil"},{"name":"Clinical Research Unit Fluminense Federal University  Niter\u00f3i Brazil"},{"name":"Postgraduate Program, School of Dentistry Fluminense Federal University  Nova Friburgo Brazil"},{"name":"Specific Formation Department, School of Dentistry of Nova Friburgo Fluminense Federal University  Nova Friburgo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jhenyfer","family":"da Silva\u00a0Tavares","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Fluminense Federal University  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila da Silva","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Postgraduate Program, School of Dentistry Fluminense Federal University  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erlange Andrade Borges","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program, School of Dentistry Fluminense Federal University  Nova Friburgo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-7234","authenticated-orcid":false,"given":"Flares","family":"Baratto\u2010Filho","sequence":"additional","affiliation":[{"name":"University of Tuiuti  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-2526","authenticated-orcid":false,"given":"Erika Calvano","family":"K\u00fcchler","sequence":"additional","affiliation":[{"name":"University of Tuiuti  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-0935","authenticated-orcid":false,"given":"Alice Corr\u00eaa","family":"Silva\u2010Sousa","sequence":"additional","affiliation":[{"name":"Restorative Dentistry Department, School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7696-7600","authenticated-orcid":false,"given":"Manoel Dami\u00e3o","family":"Sousa\u2010Neto","sequence":"additional","affiliation":[{"name":"Restorative Dentistry Department, School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-6958","authenticated-orcid":false,"given":"Leonardo Santos","family":"Antunes","sequence":"additional","affiliation":[{"name":"Postgraduate Program, School of Dentistry Fluminense Federal University  Niter\u00f3i Brazil"},{"name":"Clinical Research Unit Fluminense Federal University  Niter\u00f3i Brazil"},{"name":"Postgraduate Program, School of Dentistry Fluminense Federal University  Nova Friburgo Brazil"},{"name":"Specific Formation Department, School of Dentistry of Nova Friburgo Fluminense Federal University  Nova Friburgo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"2","article-title":"Pathogenesis of apical periodontitis: a literature review","volume":"4","author":"Graunaite I","year":"2012","journal-title":"J Oral Maxillofac Res"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.07.007"},{"key":"e_1_2_8_4_1","first-page":"408","volume-title":"Essential endodontology: prevention and treatment of apical periodontitis","author":"Friedman S","year":"2008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-775720140140"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440202205113"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13756"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.03.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.01.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2005.10.004"},{"issue":"40","key":"e_1_2_8_11_1","first-page":"94","article-title":"Gene polymorphisms in periodontal health and disease","volume":"2006","author":"Takashiba S","year":"2000","journal-title":"Periodontol 2000"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006918200"},{"issue":"43","key":"e_1_2_8_13_1","first-page":"102","article-title":"The role of genetic polymorphisms in periodontitis","volume":"2007","author":"Yoshie H","year":"2000","journal-title":"Periodontol 2000"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.06.025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510391792"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37441-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292706"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(98)00060-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12315"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035006369.x"},{"key":"e_1_2_8_21_1","first-page":"3929","article-title":"Mechanism and role of nitric oxide signaling in periodontitis","volume":"18","author":"Wang Y","year":"2019","journal-title":"Exp Ther Med"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1999.00203.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.11.011"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0603252"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.323"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13401"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13841"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.11.014"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000022"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.10.022"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.10.006"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.05.006"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00119.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070625"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572012000400013"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.157801"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00806.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00413.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14486"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.2954"},{"key":"e_1_2_8_41_1","first-page":"11","article-title":"Disturbed bone remodelling activity varies in different stages of experimental, gradually progressive apical periodontitis in rats. Int","volume":"11","author":"Xu R","year":"2019","journal-title":"J Oral Sci"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12688"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10122707"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00603.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2007.00423.x"},{"key":"e_1_2_8_46_1","first-page":"8","article-title":"The pathogenic effects of Fusobacterium nucleatum on the proliferation, osteogenic differentiation, and transcriptome of osteoblasts. Front cell","volume":"8","author":"Gao H","year":"2020","journal-title":"Dev Biol"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201600926"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2016-0464"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.11.027"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12403"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.10.019"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.6.1015"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2013.17"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1231-0"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001958"}],"container-title":["Australian Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aej.12796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T16:56:20Z","timestamp":1703696180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aej.12796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,19]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/aej.12796"],"URL":"https:\/\/doi.org\/10.1111\/aej.12796","archive":["Portico"],"relation":{},"ISSN":["1329-1947","1747-4477"],"issn-type":[{"type":"print","value":"1329-1947"},{"type":"electronic","value":"1747-4477"}],"subject":[],"published":{"date-parts":[[2023,9,19]]},"assertion":[{"value":"2023-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}