{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:31:50Z","timestamp":1789623110572,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>This study's objective was to compare the cytokine expression of IL\u20108 in periapical tissues of single\u2010rooted teeth with symptomatic apical periodontitis (SAP) before and after root canal treatments. As well as, comparing IL\u20108 levels in peri\u2010apical tissues between vital and necrotic teeth with SAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Thirty\u2010six patients were allocated according to their pulp status into two experimental groups (<jats:italic>n<\/jats:italic>\u2009=\u200918) receiving the same treatment protocol; group 1: Vital pulps with SAP, and group 2: non\u2010vital pulps with SAP. Conventional endodontic treatment was done on two visits; isolation and disinfection of the operative field were undertaken, and two\u2010stage access cavity preparation was implemented. The first pre\u2010instrumentation peri\u2010apical sample (S1) was collected prior to cleaning and shaping procedures. A 2.5% NaOCl irrigation was used to thoroughly irrigate the canal after performing root canal preparation utilising the ProTaper Next (PTN) rotary system. After 1\u2009week, the second post\u2010instrumentation peri\u2010apical sample (S2) was collected. Using an ELISA kit, the quantity of IL\u20108 was evaluated following the collection of all samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all pre\u2010instrumentation samples, IL\u20108 was detected (100%). The level of IL\u20108 expression was significantly decreased from the S1 to S2 of all samples (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The intra\u2010group comparison showed a statistically significant reduction in the level of IL\u20108 expression between S1 and S2 in both vital and non\u2010vital groups where <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001* in both groups. The inter\u2010group comparison of levels of IL\u20108 expression (vital and non\u2010vital) revealed a significant difference between both groups regarding the pretreatment sample with the higher levels of IL\u20108 shown in the non\u2010vital group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). While in the post\u2010treatment sample, both groups showed a significant reduction in the level of IL\u20108 expression but the difference between them was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.226).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Root canal instrumentation seems to be efficient in decreasing the levels of anti\u2010inflammatory cytokines, namely IL\u20108. Further research should clarify how intra\u2010canal medicaments affect inflammatory mediator levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aej.12803","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:12:31Z","timestamp":1697026351000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cytokine expression of <scp>IL<\/scp>\u20108 before and after root canal treatment in patients with symptomatic apical periodontitis: A clinical trial"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8158-7688","authenticated-orcid":false,"given":"Sarah Samir","family":"Abouelenien","sequence":"first","affiliation":[{"name":"Endodontics Department, Faculty of Dentistry Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfat 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