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Data analysis was performed using the chi\u2010square test, <jats:italic>t<\/jats:italic>\u2010test, and multiple logistic regression analysis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The prevalence of MMC and isthmus was 15.2% and 40.6%, respectively. The average dentinal thickness in the danger zone was 1.61\u2009\u00b1\u20090.14\u2009mm. Patients younger than 40\u2009years were two times more likely to have MMC (odds ratio [OR]\u2009=\u20092.204). Additionally, for every 1\u2009mm reduction in the MB\u2010ML orifice distance, the likelihood of detection of MMC in MFM nearly doubled (OR\u2009=\u20091.738). Furthermore, MFMs with MB\u2010ML isthmus were five times more likely to exhibit MMC than those without it (OR\u2009=\u20094.756). The findings revealed that the prevalence of MMC and isthmus in MFMs is high and suggested that anatomical and demographic variables can serve as valuable indicators for clinicians in anticipating their presence.<\/jats:p>","DOI":"10.1111\/aej.12807","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:48:53Z","timestamp":1698666533000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and anatomic associations of middle mesial canals and isthmi in mandibular first molars: A <scp>CBCT\u2010based<\/scp> study in a Northern Chinese population"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4950-043X","authenticated-orcid":false,"given":"Jiaojiao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Stomatology General Hospital of Northern Theater Command  Shenyang 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