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Sixty patients diagnosed with symptomatic irreversible pulpitis and apical periodontitis in mandibular molar were divided into two groups. Group SR received ibuprofen SR 800\u2009mg and group PL received placebo capsule 1\u2009h before 3.6\u2009mL articaine BI injection. Pain was recorded using a modified visual analogue scale and postoperatively at intervals 6, 24 and 48\u2009h. Group SR showed a significantly higher anaesthetic success rate (73.3%) compared to group PL (46.7%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Intraoperative and postoperative pain was significantly higher in group PL compared to group SR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Premedication of ibuprofen SR improved the efficacy of primary BI in mandibular molars with symptomatic irreversible pulpitis and decreased postoperative pain at 6 and 48\u2009h.<\/jats:p>","DOI":"10.1111\/aej.12839","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T05:29:29Z","timestamp":1711430969000},"page":"227-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of ibuprofen sustained release oral premedication on intraoperative and postoperative pain: A randomised clinical trial"],"prefix":"10.1111","volume":"50","author":[{"given":"Mariam Ahmed","family":"Hossam","sequence":"first","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa Abdelsalam","family":"El\u00a0Baz","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Won","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, School of Dentistry Dental Research Institute, Dental and Life Science Institute, Pusan National University  Yangsan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8032-1194","authenticated-orcid":false,"given":"Hyeon\u2010Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, School of Dentistry Dental Research Institute, Dental and Life Science Institute, Pusan National University  Yangsan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5175-0010","authenticated-orcid":false,"given":"Mohamed Mohsen","family":"Abielhassan","sequence":"additional","affiliation":[{"name":"Department of Endodontics, 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