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This study investigated melatonin's effects, known for its antioxidant and anti\u2010inflammatory properties, on experimentally induced apical periodontitis in rats. Three groups of rats were studied: control, apical periodontitis and apical periodontitis with melatonin treatment. Proinflammatory cytokines and enzyme levels in blood serum were measured, and micro\u2010CT analysis assessed bone resorption. Results showed significantly elevated cytokines and enzyme levels in the apical periodontitis group compared to the control. However, in the melatonin\u2010treated group, these levels were significantly reduced (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01\u20130.001). Micro\u2010CT analysis indicated decreased periapical resorption cavity volume and surface area with melatonin treatment. This suggests that systemic melatonin administration can mitigate inflammation and reduce bone resorption in experimentally induced apical periodontitis in rats, potentially holding promise for human endodontic disease treatment pending further research.<\/jats:p>","DOI":"10.1111\/aej.12841","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T07:05:40Z","timestamp":1711004740000},"page":"218-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of melatonin against experimentally induced apical periodontitis in rats"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0483-1736","authenticated-orcid":false,"given":"D.","family":"K\u0131rm\u0131z\u0131","sequence":"first","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry Near East University  Nicosia, Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-9290","authenticated-orcid":false,"given":"A. \u00d6.","family":"Sehirli","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Dentistry Near East University  Nicosia, Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-5369","authenticated-orcid":false,"given":"S.","family":"Sayiner","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Near East University  Nicosia, Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6768-0176","authenticated-orcid":false,"given":"K.","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Radiology, Faculty of Dentistry Ankara University  Ankara Turkey"},{"name":"Medical Design Application and Research Center (MEDITAM) Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-8751","authenticated-orcid":false,"given":"A.","family":"Sebai","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry Near East University  Nicosia, Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7281-508X","authenticated-orcid":false,"given":"U.","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry Near East University  Nicosia, Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2010.08.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/11355"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90044-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005000200004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13138"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.02.021"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.01.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.09.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.24126\/jobrc.2020.14.1.584"},{"key":"e_1_2_8_11_1","first-page":"95","article-title":"Oral fluid based biomarkers in periodontal disease: part 1. 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