{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:59:14Z","timestamp":1787770754422,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.843023\/2023\u201000"],"award-info":[{"award-number":["88887.843023\/2023\u201000"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sodium hypochlorite (NaOCl), ethylenediaminetetraacetic acid (EDTA), and calcium hydroxide (Ca(OH)<jats:sub>2<\/jats:sub>) are used in root canal treatment. However, further research is needed to assess their effectiveness at time points not considered in previous guidelines. This review complements the systematic review by Rossi\u2010Fedele and R\u00f6dig (2023) by considering time points excluded by the latter. A search was conducted in PubMed\u2010MEDLINE, Scopus, EMBASE, Google Scholar, and repositories between March and May 2024. Four studies met the inclusion criteria, providing data from 212 teeth for irrigation and 108 for dressings. No significant differences in pain reduction within 7\u2009days or radiographic reduction of apical lesion size were found between 2% chlorhexidine, 5.25% NaOCl, EDTA, and various NaOCl concentrations. Single and multiple visit protocols also showed no significant differences in postoperative pain.\u00a0Two studies had a \u2018low risk\u2019 of bias and two \u2018some concerns\u2019. Evidence suggests that Ca(OH)<jats:sub>2<\/jats:sub> dressings may not offer additional benefits.<\/jats:p>","DOI":"10.1111\/aej.12918","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T11:20:42Z","timestamp":1737976842000},"page":"209-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Root Canal Irrigation and Dressing for the Treatment of Asymptomatic Apical Periodontitis: A Systematic Review Assessing Complementary Timeframes"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-4861","authenticated-orcid":false,"given":"Felipe","family":"Immich","sequence":"first","affiliation":[{"name":"Graduate Program in Dentistry, School of Dentistry Federal University of Pelotas  Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3049-4449","authenticated-orcid":false,"given":"Tina","family":"R\u00f6dig","sequence":"additional","affiliation":[{"name":"Department for Preventive Dentistry, Periodontology and Cariology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-561X","authenticated-orcid":false,"given":"Philipp","family":"Kanzow","sequence":"additional","affiliation":[{"name":"Department for Preventive Dentistry, Periodontology and Cariology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-5158","authenticated-orcid":false,"given":"Evandro","family":"Piva","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, School of Dentistry Federal University of Pelotas  Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8287-1226","authenticated-orcid":false,"given":"Giampiero","family":"Rossi\u2010Fedele","sequence":"additional","affiliation":[{"name":"Adelaide Dental School University of Adelaide  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13974"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13777"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13830"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12380"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.11.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.02.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13467"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008948.pub2"},{"key":"e_1_2_9_11_1","article-title":"Single Versus Multiple Visits for Endodontic Treatment of Permanent Teeth","volume":"2023","author":"Mergoni G.","year":"2022","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2009.01671.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01323.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01197.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2005.00955.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604.ch8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_9_19_1","article-title":"Influence of Irrigating Solution on Postoperative Pain Following Single\u2010Visit Endodontic Treatment: Randomized Clinical Trial","volume":"78","author":"Almeida G.","year":"2012","journal-title":"Journal of the Canadian Dental Association"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.01.003"},{"issue":"10","key":"e_1_2_9_21_1","first-page":"1429","article-title":"Comparison of Frequency of Post\u2010Obturation Pain of Single Versus Multiple Visit Root Canal Treatment of Necrotic Teeth With Infected Root Canals. 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