{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T12:29:22Z","timestamp":1764592162649,"version":"3.46.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the impact of post\u2010treatment apical periodontitis on microbial DNA in patients' blood circulation. Samples from the root apex, periapical lesion and peripheral blood of 11 patients, along with peripheral blood from nine healthy controls, were analysed using next\u2010generation sequencing. The microbial DNA composition, diversity and linear discriminant analysis effect size were analysed. The SourceTracker was applied to trace microorganisms of peripheral blood.\n                    <jats:italic>Proteobacteria<\/jats:italic>\n                    dominated peripheral blood and periapical lesions, while\n                    <jats:italic>Actinobacteria<\/jats:italic>\n                    prevailed in the root apex. Patients exhibited higher microbial diversity in blood but reduced \u03b1\u2010diversity in the root apex compared to other sites. Moreover,\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    , as well as\n                    <jats:italic>Aliihoeflea<\/jats:italic>\n                    ,\n                    <jats:italic>Oceanicaulis<\/jats:italic>\n                    ,\n                    <jats:italic>Comamonas<\/jats:italic>\n                    ,\n                    <jats:italic>Shigella<\/jats:italic>\n                    and\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    , showed increased relative abundance in the blood of patients. Additionally, the root apex contributed 26% and the periapical lesion contributed 76% to peripheral blood for the bacteria. These findings suggested unique microbial translocation in post\u2010treatment apical periodontitis patients.\n                  <\/jats:p>","DOI":"10.1111\/aej.12942","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T03:21:11Z","timestamp":1743304871000},"page":"298-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post\u2010Treatment Apical Periodontitis: Endodontic Infection Contributes to Circulating Microbial\n                    <scp>DNA<\/scp>"],"prefix":"10.1111","volume":"51","author":[{"given":"Yanglin","family":"Zeng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5278-288X","authenticated-orcid":false,"given":"Mudan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Muti\u2010Disciplinary Treatment Guiyang Hospital of Stomatology  Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Stomatology Chengdu Second People's Hospital  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-2013","authenticated-orcid":false,"given":"Dongzhe","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-5729","authenticated-orcid":false,"given":"Dingming","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1038\/s41579-023-00963-6"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.3390\/microorganisms12091797"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.3389\/fcimb.2020.577485"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.3389\/fcimb.2021.649925"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1111\/iej.13640"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1111\/iej.14046"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1016\/j.joen.2021.09.010"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1016\/j.tem.2020.01.013"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1080\/19490976.2022.2029674"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1177\/0022034520924633"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.3390\/ijms24065517"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1111\/iej.13909"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1111\/iej.13893"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1111\/iej.13512"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.3389\/fcimb.2021.798367"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.3389\/fcimb.2022.980157"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1111\/iej.13655"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1038\/s41598-021-85484-z"},{"unstructured":"\u201cMicrobial Analysis of Umbilical Cord Blood Reveals Novel Pathogens Associated With Stillbirth and Early Preterm Birth \u201dhttps:\/\/pubmed.ncbi.nlm.nih.gov\/35993728\/.","key":"e_1_2_10_20_1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.1038\/nmeth.1650"},{"issue":"5","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02036-22","article-title":"Microbial Analysis of Umbilical Cord Blood Reveals Novel Pathogens Associated With Stillbirth and Early Preterm Birth","volume":"13","author":"Haar E. 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