{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:27:33Z","timestamp":1767162453853,"version":"build-2238731810"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Endodontic J"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Conservative access cavity (ConsAC) has been increasingly advocated to preserve tooth structure, but its effect on disinfection efficacy against complex biofilms remains unclear. This study evaluated the effectiveness of different irrigants combined with Ni\u2010Ti instruments on mixed biofilms of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    in maxillary premolars with ConsAC or traditional access cavity (TradAC). A total of 208 extracted intact premolars were divided into ConsAC and TradAC groups. Root canals were infected with mixed biofilms and treated with 2.5% NaOCl, 2% CHX or 1% farnesol, followed by preparation using ProTaper Gold (PTG) or XP\u2010endo Shaper (XPS). Efficacy was assessed using CFU counting, SEM, and CLSM. PTG was more effective than XPS under the same conditions. NaOCl showed superior antimicrobial activity compared with CHX and farnesol. TradAC achieved better microbial reduction than ConsAC. This study provides evidence\u2010based insights into the disinfection performance of different irrigation\u2010instrument combinations under varying access designs.\n                  <\/jats:p>","DOI":"10.1111\/aej.12947","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T03:37:47Z","timestamp":1746243467000},"page":"336-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro Antimicrobial Efficacy of Irrigants With Ni\u2010Ti Instruments on Mixed Biofilm in Premolar Root Canals With Conservative Access Cavity"],"prefix":"10.1111","volume":"51","author":[{"given":"Yun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Endodontics The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases Nanjing Medical University  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